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• W2792742676 endingPage "e0193539" @default.
• W2792742676 startingPage "e0193539" @default.
• W2792742676 abstract "Kawasaki disease (KD), the leading cause of acquired heart disease in children, primarily affects infants and toddlers. Investigations on immune responses during KD are hampered by a limited understanding of normal immune responses in these ages. It's well known that Infants have poorer vaccine responses and difficulty with maintaining prolonged serum immunity, but there are few studies on human infants detailing immune deficiencies. Limited studies propose an inability to maintain life-long bone marrow plasma cells. Plasmablasts are a transitional cell form of B cells that lead to long-term Plasma cells. Plasmablasts levels rise in the peripheral blood after exposure to a foreign antigen. In adult studies, these responses are both temporally and functionally well characterized. To date, there have been few studies on plasmablasts in the predominant age range of KD.Children presenting to an urban pediatric emergency room undergoing laboratory evaluation, who had concern of KD or had fever and symptoms overlapping those of KD, were recruited. Peripheral blood mononuclear cells were isolated and evaluated utilizing flow cytometry with specific B cell markers from 18 KD subjects and 69 febrile controls.Plasmablast numbers and temporal formation are similar between infectious disease controls and KD subjects. In both groups, infants have diminished plasmablast responses compared to older children.In this single-time point survey, infants have a blunted peripheral plasmablast response. Overall, similar plasmablast responses in KD and controls support an infectious disease relationship to KD. Future time-course studies of plasmablasts in infants are warranted as this phenomenon may contribute to observed immune responses in this age group." @default.
• W2792742676 created "2018-03-29" @default.
• W2792742676 creator A5046589820 @default.
• W2792742676 creator A5049834559 @default.
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• W2792742676 date "2018-03-26" @default.
• W2792742676 modified "2023-10-12" @default.
• W2792742676 title "Suppressed plasmablast responses in febrile infants, including children with Kawasaki disease" @default.
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• W2792742676 doi "https://doi.org/10.1371/journal.pone.0193539" @default.
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