Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792783253> ?p ?o ?g. }
- W2792783253 endingPage "390" @default.
- W2792783253 startingPage "372" @default.
- W2792783253 abstract "Dysfunction of the autonomic nervous system afflicts most patients with Parkinson disease and other synucleinopathies such as dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure, reducing quality of life and increasing mortality. For example, gastrointestinal dysfunction can lead to impaired drug pharmacodynamics causing a worsening in motor symptoms, and neurogenic orthostatic hypotension can cause syncope, falls, and fractures. When recognized, autonomic problems can be treated, sometimes successfully. Discontinuation of potentially causative/aggravating drugs, patient education, and nonpharmacological approaches are useful and should be tried first. Pathophysiology-based pharmacological treatments that have shown efficacy in controlled trials of patients with synucleinopathies have been approved in many countries and are key to an effective management. Here, we review the treatment of autonomic dysfunction in patients with Parkinson disease and other synucleinopathies, summarize the nonpharmacological and current pharmacological therapeutic strategies including recently approved drugs, and provide practical advice and management algorithms for clinicians, with focus on neurogenic orthostatic hypotension, supine hypertension, dysphagia, sialorrhea, gastroparesis, constipation, neurogenic overactive bladder, underactive bladder, and sexual dysfunction. © 2018 International Parkinson and Movement Disorder Society" @default.
- W2792783253 created "2018-03-29" @default.
- W2792783253 creator A5050948560 @default.
- W2792783253 creator A5073518656 @default.
- W2792783253 date "2018-03-01" @default.
- W2792783253 modified "2023-10-18" @default.
- W2792783253 title "Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies" @default.
- W2792783253 cites W1128461530 @default.
- W2792783253 cites W114637653 @default.
- W2792783253 cites W1505350439 @default.
- W2792783253 cites W1529965501 @default.
- W2792783253 cites W1550562594 @default.
- W2792783253 cites W1564387586 @default.
- W2792783253 cites W1566264161 @default.
- W2792783253 cites W1579782291 @default.
- W2792783253 cites W1593113894 @default.
- W2792783253 cites W1598029032 @default.
- W2792783253 cites W165094843 @default.
- W2792783253 cites W1744837515 @default.
- W2792783253 cites W1761627028 @default.
- W2792783253 cites W1819990028 @default.
- W2792783253 cites W1843188283 @default.
- W2792783253 cites W1890425573 @default.
- W2792783253 cites W1900900295 @default.
- W2792783253 cites W1902151435 @default.
- W2792783253 cites W1914579162 @default.
- W2792783253 cites W1947901277 @default.
- W2792783253 cites W1955567615 @default.
- W2792783253 cites W1964084602 @default.
- W2792783253 cites W1964266581 @default.
- W2792783253 cites W1965713015 @default.
- W2792783253 cites W1965805548 @default.
- W2792783253 cites W1966941681 @default.
- W2792783253 cites W1967114240 @default.
- W2792783253 cites W1967300763 @default.
- W2792783253 cites W1967860946 @default.
- W2792783253 cites W1969350622 @default.
- W2792783253 cites W1969601645 @default.
- W2792783253 cites W1971211368 @default.
- W2792783253 cites W1972263158 @default.
- W2792783253 cites W1973352953 @default.
- W2792783253 cites W1974319588 @default.
- W2792783253 cites W1975910973 @default.
- W2792783253 cites W1976603254 @default.
- W2792783253 cites W1976968148 @default.
- W2792783253 cites W1977029823 @default.
- W2792783253 cites W1979288968 @default.
- W2792783253 cites W1979576015 @default.
- W2792783253 cites W1980385871 @default.
- W2792783253 cites W1982247537 @default.
- W2792783253 cites W1983045143 @default.
- W2792783253 cites W1983067632 @default.
- W2792783253 cites W1986437087 @default.
- W2792783253 cites W1987794550 @default.
- W2792783253 cites W1988920656 @default.
- W2792783253 cites W1990723779 @default.
- W2792783253 cites W1993471376 @default.
- W2792783253 cites W1995281235 @default.
- W2792783253 cites W1998303227 @default.
- W2792783253 cites W1998325806 @default.
- W2792783253 cites W1999865361 @default.
- W2792783253 cites W2000016536 @default.
- W2792783253 cites W2000120626 @default.
- W2792783253 cites W2000468077 @default.
- W2792783253 cites W2002221116 @default.
- W2792783253 cites W2003959107 @default.
- W2792783253 cites W2005319441 @default.
- W2792783253 cites W2008658566 @default.
- W2792783253 cites W2009249642 @default.
- W2792783253 cites W2010934845 @default.
- W2792783253 cites W2010968308 @default.
- W2792783253 cites W2011540686 @default.
- W2792783253 cites W2011881593 @default.
- W2792783253 cites W2014179488 @default.
- W2792783253 cites W2014267695 @default.
- W2792783253 cites W2014594848 @default.
- W2792783253 cites W2015793733 @default.
- W2792783253 cites W2020203841 @default.
- W2792783253 cites W2020272574 @default.
- W2792783253 cites W2020920438 @default.
- W2792783253 cites W2021069712 @default.
- W2792783253 cites W2021521949 @default.
- W2792783253 cites W2023881756 @default.
- W2792783253 cites W2025005092 @default.
- W2792783253 cites W2026387951 @default.
- W2792783253 cites W2028064753 @default.
- W2792783253 cites W2029445782 @default.
- W2792783253 cites W2029966249 @default.
- W2792783253 cites W2032863577 @default.
- W2792783253 cites W2033185924 @default.
- W2792783253 cites W2033711158 @default.
- W2792783253 cites W2034151625 @default.
- W2792783253 cites W2036887714 @default.
- W2792783253 cites W2038471991 @default.
- W2792783253 cites W2040080950 @default.
- W2792783253 cites W2040667783 @default.
- W2792783253 cites W2041741770 @default.
- W2792783253 cites W2042975848 @default.