FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792819064> ?p ?o ?g. }

• W2792819064 endingPage "115.e3" @default.
• W2792819064 startingPage "107" @default.
• W2792819064 abstract "To control for confounding by indication in comparative (drug) effectiveness studies, propensity score (PS) methods may be used. Since childhood diseases or outcomes often present as acute events, we compared the effect of using different look-back periods in electronic health-care data, to construct PSs. This was applied in our research on the effect of a combination of inhaled corticosteroids/long-acting beta-2 agonists (ICS + LABA), either as fixed combination or used as loose combination (2 separate inhaler devices) in the prevention of severe asthma exacerbations.We created a cohort of children (5-17 years) diagnosed with asthma from the Dutch Integrated Primary Care information database. Within this cohort, we identified new users of ICS + LABA, either as fixed combination or loose combination (2 separate inhaler devices). The outcome of interest was severe asthma exacerbations. PSs for type of treatment were created using comorbidity and drug use history in different time windows: 1 week, 1 month, 3 months, 1 year, and full history prior to the start of treatment. PSs were used for matching subjects in both exposure groups. Time to first asthma exacerbation was analyzed with Cox proportional hazard regression. The results were compared with published clinical trials.Of 39,682 asthmatic children, 3,500 (8.8%) were new users of either ICS + LABA fixed (3,324 [95.0%]) or loose (176 [5.0%]). The crude hazard ratio (HR) for a severe asthma exacerbation, comparing ICS + LABA fixed to loose was 0.37 (95% confidence interval [CI]: 0.20-0.66). PS-matched HRs (1 week, 1 month, 3 month, 1 year, and full history) were 0.48 (95% CI: 0.22-1.04); 0.60 (95% CI: 0.26-1.38), 0.69 (95% CI: 0.31-1.57), 0.56 (CI: 0.25-1.24), and 0.58 (CI: 0.24-1.36), respectively.PS matching can be used to control for confounding in pediatric comparative (drug) effectiveness studies, the impact of different look-back periods to implement the PS is important. Controlling for confounders occurring in the 3 months preceding drug exposure may yield results comparable to clinical trial results." @default.
• W2792819064 created "2018-03-29" @default.
• W2792819064 creator A5004803528 @default.
• W2792819064 creator A5014850022 @default.
• W2792819064 creator A5028802376 @default.
• W2792819064 creator A5055137783 @default.
• W2792819064 creator A5059165461 @default.
• W2792819064 creator A5067220335 @default.
• W2792819064 creator A5082236476 @default.
• W2792819064 date "2018-09-01" @default.
• W2792819064 modified "2023-09-26" @default.
• W2792819064 title "Choice of time period to identify confounders for propensity score matching, affected the estimate: a retrospective cohort study of drug effectiveness in asthmatic children" @default.
• W2792819064 cites W1878621938 @default.
• W2792819064 cites W1948059877 @default.
• W2792819064 cites W1964779747 @default.
• W2792819064 cites W1965384812 @default.
• W2792819064 cites W1974588488 @default.
• W2792819064 cites W1980546744 @default.
• W2792819064 cites W1981535076 @default.
• W2792819064 cites W1989065471 @default.
• W2792819064 cites W1992987825 @default.
• W2792819064 cites W1999871132 @default.
• W2792819064 cites W2000991311 @default.
• W2792819064 cites W2002646960 @default.
• W2792819064 cites W2012579017 @default.
• W2792819064 cites W2016357017 @default.
• W2792819064 cites W2034967838 @default.
• W2792819064 cites W2036193982 @default.
• W2792819064 cites W2040154500 @default.
• W2792819064 cites W2043614249 @default.
• W2792819064 cites W2045861148 @default.
• W2792819064 cites W2048576379 @default.
• W2792819064 cites W2052806549 @default.
• W2792819064 cites W2071295142 @default.
• W2792819064 cites W2073225472 @default.
• W2792819064 cites W2086038978 @default.
• W2792819064 cites W2092290289 @default.
• W2792819064 cites W2102520493 @default.
• W2792819064 cites W2107838877 @default.
• W2792819064 cites W2110818436 @default.
• W2792819064 cites W2111635289 @default.
• W2792819064 cites W2121545123 @default.
• W2792819064 cites W2121675303 @default.
• W2792819064 cites W2137254230 @default.
• W2792819064 cites W2138153404 @default.
• W2792819064 cites W2150291618 @default.
• W2792819064 cites W2150750343 @default.
• W2792819064 cites W2154872949 @default.
• W2792819064 cites W2155916653 @default.
• W2792819064 cites W2159805452 @default.
• W2792819064 cites W2161800479 @default.
• W2792819064 cites W2168458505 @default.
• W2792819064 cites W2401337239 @default.
• W2792819064 cites W2473273192 @default.
• W2792819064 cites W2515567006 @default.
• W2792819064 cites W2528447507 @default.
• W2792819064 cites W4248368334 @default.
• W2792819064 cites W4233637714 @default.
• W2792819064 doi "https://doi.org/10.1016/j.jclinepi.2018.01.008" @default.
• W2792819064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29378305" @default.
• W2792819064 hasPublicationYear "2018" @default.
• W2792819064 type Work @default.
• W2792819064 sameAs 2792819064 @default.
• W2792819064 citedByCount "2" @default.
• W2792819064 countsByYear W27928190642020 @default.
• W2792819064 countsByYear W27928190642022 @default.
• W2792819064 crossrefType "journal-article" @default.
• W2792819064 hasAuthorship W2792819064A5004803528 @default.
• W2792819064 hasAuthorship W2792819064A5014850022 @default.
• W2792819064 hasAuthorship W2792819064A5028802376 @default.
• W2792819064 hasAuthorship W2792819064A5055137783 @default.
• W2792819064 hasAuthorship W2792819064A5059165461 @default.
• W2792819064 hasAuthorship W2792819064A5067220335 @default.
• W2792819064 hasAuthorship W2792819064A5082236476 @default.
• W2792819064 hasConcept C126322002 @default.
• W2792819064 hasConcept C167135981 @default.
• W2792819064 hasConcept C17923572 @default.
• W2792819064 hasConcept C187212893 @default.
• W2792819064 hasConcept C201903717 @default.
• W2792819064 hasConcept C207103383 @default.
• W2792819064 hasConcept C2776042228 @default.
• W2792819064 hasConcept C2776136866 @default.
• W2792819064 hasConcept C2777014857 @default.
• W2792819064 hasConcept C2779871671 @default.
• W2792819064 hasConcept C2780261241 @default.
• W2792819064 hasConcept C44249647 @default.
• W2792819064 hasConcept C50382708 @default.
• W2792819064 hasConcept C71924100 @default.
• W2792819064 hasConcept C72563966 @default.
• W2792819064 hasConcept C77350462 @default.
• W2792819064 hasConceptScore W2792819064C126322002 @default.
• W2792819064 hasConceptScore W2792819064C167135981 @default.
• W2792819064 hasConceptScore W2792819064C17923572 @default.
• W2792819064 hasConceptScore W2792819064C187212893 @default.
• W2792819064 hasConceptScore W2792819064C201903717 @default.
• W2792819064 hasConceptScore W2792819064C207103383 @default.
• W2792819064 hasConceptScore W2792819064C2776042228 @default.
• W2792819064 hasConceptScore W2792819064C2776136866 @default.

• next