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• W2792830624 abstract "In the industrial oleaginous fungus Mortierella alpina, the arachidonic acid (AA; C20:4; ω-6) fraction can reach 50% of the total fatty acids (TFAs) in vivo. However, the eicosapentaenoic acid (EPA; C20:5; ω-3) fraction is less than 3% when this fungus is cultivated at a low temperature (12°C). Omega-3 fatty acid desaturase is a key enzyme in ω-3 long-chain polyunsaturated fatty acids biosynthesis pathways. To enhance EPA production, we transformed the ω-3 fatty acid desaturase (PaD17), which exhibits strong Δ-17 desaturase activity, into M. alpina, thus increasing the AA to EPA conversion rate to 49.8%. This PaD17-harboring M. alpina reconstruction strain produced 617 mg L-1 of EPA at room temperature in broth medium, this yield was increased to 1.73 g L-1 after culture medium optimization (i.e., about threefold higher than that under original culture conditions), with concomitant respective increases in dry cell weight and TFA content to 16.55 and 6.46 g L-1. These findings suggest a new platform for the future industrial production of EPA." @default.
• W2792830624 created "2018-03-29" @default.
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• W2792830624 date "2018-01-22" @default.
• W2792830624 modified "2023-09-30" @default.
• W2792830624 title "Application of a ω-3 Desaturase with an Arachidonic Acid Preference to Eicosapentaenoic Acid Production in Mortierella alpina" @default.
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• W2792830624 doi "https://doi.org/10.3389/fbioe.2017.00089" @default.
• W2792830624 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5786553" @default.
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