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• W2792875772 abstract "KU-596 is a second-generation C-terminal heat shock protein 90 KDa (Hsp90) modulator based on the natural product, novobiocin. KU-596 has been shown to induce Hsp70 levels and manifest neuroprotective activity through induction of the heat shock response. A ring-constrained analog of KU-596 was designed and synthesized to probe its binding orientation and ability to induce Hsp70 levels. Compound 2 was found to exhibit comparable or increased activity compared to KU-596, which is under clinical investigation for the treatment of neuropathy." @default.
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• W2792875772 date "2018-09-01" @default.
• W2792875772 modified "2023-10-16" @default.
• W2792875772 title "Synthesis and evaluation of a ring-constrained Hsp90 C-terminal inhibitor that exhibits neuroprotective activity" @default.
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• W2792875772 doi "https://doi.org/10.1016/j.bmcl.2018.03.071" @default.
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