Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792894890> ?p ?o ?g. }
- W2792894890 endingPage "130" @default.
- W2792894890 startingPage "122" @default.
- W2792894890 abstract "Neck pain from cervical facet loading is common and induces inflammation and upregulation of nerve growth factor (NGF) that can sensitize the joint afferents. Yet, the mechanisms by which these occur and whether afferents can be pre-conditioned by certain nonpainful stimuli are unknown. This study tested the hypothesis that a nonpainful mechanical or chemical insult predisposes a facet joint to generate pain after a later exposure to typically nonpainful distraction.Rats were exposed to either a nonpainful distraction or an intra-articular subthreshold dose of NGF followed by a nonpainful distraction two days later. Mechanical hyperalgesia was measured daily and C6 dorsal root ganglia (DRG) tissue was assayed for NGF and matrix metalloproteinase-3 (MMP-3) expression on day 7.The second distraction increased joint displacement and strains compared to its first application (p = 0.0011). None of the initial exposures altered behavioral sensitivity in either of the groups being pre-conditioned or in controls; but, sensitivity was established in both groups receiving a second distraction within one day that lasted until day 7 (p < 0.024). NGF expression in the DRG was increased in both groups undergoing a pre-conditioning exposure (p < 0.0232). Similar findings were observed for MMP-3 expression, with a pre-conditioning exposure increasing levels after an otherwise nonpainful facet distraction.These findings suggest that nonpainful insults to the facet joint, when combined, can generate painful outcomes, possibly mediated by upregulation of MMP-3 and mature NGF." @default.
- W2792894890 created "2018-03-29" @default.
- W2792894890 creator A5019632188 @default.
- W2792894890 creator A5040997688 @default.
- W2792894890 creator A5068455144 @default.
- W2792894890 creator A5080620661 @default.
- W2792894890 creator A5085252883 @default.
- W2792894890 date "2019-04-01" @default.
- W2792894890 modified "2023-10-17" @default.
- W2792894890 title "Physiologic facet capsule stretch can induce pain & upregulate matrix metalloproteinase-3 in the dorsal root ganglia when preceded by a physiological mechanical or nonpainful chemical exposure" @default.
- W2792894890 cites W1006549038 @default.
- W2792894890 cites W1256176685 @default.
- W2792894890 cites W132811261 @default.
- W2792894890 cites W1482298951 @default.
- W2792894890 cites W1547979961 @default.
- W2792894890 cites W1892427918 @default.
- W2792894890 cites W1949425569 @default.
- W2792894890 cites W1950911242 @default.
- W2792894890 cites W1965690582 @default.
- W2792894890 cites W1965779217 @default.
- W2792894890 cites W1966725920 @default.
- W2792894890 cites W1971066754 @default.
- W2792894890 cites W1971134887 @default.
- W2792894890 cites W1971501054 @default.
- W2792894890 cites W1971540589 @default.
- W2792894890 cites W1971634408 @default.
- W2792894890 cites W1971927237 @default.
- W2792894890 cites W1973268693 @default.
- W2792894890 cites W1974880258 @default.
- W2792894890 cites W1976034921 @default.
- W2792894890 cites W1976287771 @default.
- W2792894890 cites W1976484413 @default.
- W2792894890 cites W1976720112 @default.
- W2792894890 cites W1976841776 @default.
- W2792894890 cites W1977621996 @default.
- W2792894890 cites W1983287820 @default.
- W2792894890 cites W1983800020 @default.
- W2792894890 cites W1984737307 @default.
- W2792894890 cites W1989231576 @default.
- W2792894890 cites W1991616946 @default.
- W2792894890 cites W1994174812 @default.
- W2792894890 cites W1998453569 @default.
- W2792894890 cites W2000643722 @default.
- W2792894890 cites W2001376757 @default.
- W2792894890 cites W2003380091 @default.
- W2792894890 cites W2003434610 @default.
- W2792894890 cites W2003892673 @default.
- W2792894890 cites W2004395999 @default.
- W2792894890 cites W2004557173 @default.
- W2792894890 cites W2008820260 @default.
- W2792894890 cites W2009859584 @default.
- W2792894890 cites W2009955664 @default.
- W2792894890 cites W2010404343 @default.
- W2792894890 cites W2012050679 @default.
- W2792894890 cites W2012299945 @default.
- W2792894890 cites W2013411245 @default.
- W2792894890 cites W2014036182 @default.
- W2792894890 cites W2014874693 @default.
- W2792894890 cites W2017127682 @default.
- W2792894890 cites W2017537032 @default.
- W2792894890 cites W2018225482 @default.
- W2792894890 cites W2018324188 @default.
- W2792894890 cites W2019764823 @default.
- W2792894890 cites W2023392979 @default.
- W2792894890 cites W2023714013 @default.
- W2792894890 cites W2027064576 @default.
- W2792894890 cites W2027662788 @default.
- W2792894890 cites W2033703236 @default.
- W2792894890 cites W2034624992 @default.
- W2792894890 cites W2035838553 @default.
- W2792894890 cites W2035984810 @default.
- W2792894890 cites W2037043363 @default.
- W2792894890 cites W2040035374 @default.
- W2792894890 cites W2040642697 @default.
- W2792894890 cites W2046296795 @default.
- W2792894890 cites W2046310455 @default.
- W2792894890 cites W2047311691 @default.
- W2792894890 cites W2054986774 @default.
- W2792894890 cites W2055029288 @default.
- W2792894890 cites W2056710301 @default.
- W2792894890 cites W2056885349 @default.
- W2792894890 cites W2057994548 @default.
- W2792894890 cites W2061888490 @default.
- W2792894890 cites W2064264691 @default.
- W2792894890 cites W2066908475 @default.
- W2792894890 cites W2067005445 @default.
- W2792894890 cites W2067523166 @default.
- W2792894890 cites W2069158658 @default.
- W2792894890 cites W2069761333 @default.
- W2792894890 cites W2069918422 @default.
- W2792894890 cites W2070834761 @default.
- W2792894890 cites W2074311453 @default.
- W2792894890 cites W2074446731 @default.
- W2792894890 cites W2076107364 @default.
- W2792894890 cites W2087090756 @default.
- W2792894890 cites W2087454739 @default.
- W2792894890 cites W2088179197 @default.
- W2792894890 cites W2090179549 @default.