FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792901908> ?p ?o ?g. }

• W2792901908 abstract "Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor metastasis is accelerated by OSA-like IH remain to be elucidated.C57BL/6 J male mice were subjected to intravenous injection of B16F10 melanoma cells before receiving IH treatment. Then, the animals were randomly distributed into three groups (n = 8 each): normoxia (N) group, IH group, and antioxidant tempol group (IHT, exposed to IH after treatment with tempol). After the mice were sacrificed, the number and weight of lung metastatic colonies were assessed. The lung tissues with tumor metastasis were analyzed for markers of oxidative stress and inflammation and for HIF-1α using western blotting and real-time PCR (qRT-PCR). The level of reactive oxygen species (ROS) in B16F10 cell was also assessed after N, IH and IH with tempol treatments.Compared with normoxia, IH significantly increased the number and weight of mouse lung metastatic colonies. Treatment of B16F10 cells with IH significantly enhanced ROS generation. Lung tissues with tumor metastasis provided evidence of increased oxidative stress, as assessed by p22phox and SOD mRNA levels and the NRF2 protein level, as well as increased inflammation, as assessed by TNF-α and IL-6 mRNA levels and the NF-κB P65 protein level. HIF-1α protein levels were increased in response to IH treatment. Tempol, an important antioxidant, ameliorated IH-induced melanoma lung metastasis in mice and reduced oxidative stress and inflammation responses.These results support the hypothesis that oxidative stress and inflammation responses play an important role in the pathogenesis of OSA-like IH-induced melanoma lung metastasis in mice. Antioxidant intervention provides a novel strategy for the prevention and treatment of cancer in OSA populations." @default.
• W2792901908 created "2018-03-29" @default.
• W2792901908 creator A5000323703 @default.
• W2792901908 creator A5013596240 @default.
• W2792901908 creator A5022825628 @default.
• W2792901908 creator A5024648164 @default.
• W2792901908 creator A5045492083 @default.
• W2792901908 creator A5054235872 @default.
• W2792901908 creator A5064692183 @default.
• W2792901908 creator A5070808341 @default.
• W2792901908 creator A5076782425 @default.
• W2792901908 creator A5090340144 @default.
• W2792901908 date "2018-02-12" @default.
• W2792901908 modified "2023-10-14" @default.
• W2792901908 title "Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea" @default.
• W2792901908 cites W113566499 @default.
• W2792901908 cites W1567827425 @default.
• W2792901908 cites W1576829667 @default.
• W2792901908 cites W16421494 @default.
• W2792901908 cites W1958066496 @default.
• W2792901908 cites W1968816740 @default.
• W2792901908 cites W1971895086 @default.
• W2792901908 cites W1972048759 @default.
• W2792901908 cites W1977497653 @default.
• W2792901908 cites W1982030800 @default.
• W2792901908 cites W1983691058 @default.
• W2792901908 cites W1987561330 @default.
• W2792901908 cites W1991308916 @default.
• W2792901908 cites W1993505686 @default.
• W2792901908 cites W1993657306 @default.
• W2792901908 cites W1999828349 @default.
• W2792901908 cites W2000548860 @default.
• W2792901908 cites W2003533532 @default.
• W2792901908 cites W2003633558 @default.
• W2792901908 cites W2008676708 @default.
• W2792901908 cites W2015511926 @default.
• W2792901908 cites W2027112731 @default.
• W2792901908 cites W2028553108 @default.
• W2792901908 cites W2029901821 @default.
• W2792901908 cites W2031523777 @default.
• W2792901908 cites W2042250615 @default.
• W2792901908 cites W2049646399 @default.
• W2792901908 cites W2059385151 @default.
• W2792901908 cites W2077967308 @default.
• W2792901908 cites W2082170144 @default.
• W2792901908 cites W2083155989 @default.
• W2792901908 cites W2084009434 @default.
• W2792901908 cites W2084027288 @default.
• W2792901908 cites W2090559362 @default.
• W2792901908 cites W2093464982 @default.
• W2792901908 cites W2094156327 @default.
• W2792901908 cites W2095062583 @default.
• W2792901908 cites W2095844587 @default.
• W2792901908 cites W2098144345 @default.
• W2792901908 cites W2108281717 @default.
• W2792901908 cites W2109521892 @default.
• W2792901908 cites W2120788437 @default.
• W2792901908 cites W2122150741 @default.
• W2792901908 cites W2123105952 @default.
• W2792901908 cites W2126868294 @default.
• W2792901908 cites W2133396341 @default.
• W2792901908 cites W2136897807 @default.
• W2792901908 cites W2142037875 @default.
• W2792901908 cites W2148460072 @default.
• W2792901908 cites W2155779354 @default.
• W2792901908 cites W2168390541 @default.
• W2792901908 cites W225683512 @default.
• W2792901908 cites W2317846338 @default.
• W2792901908 cites W2528213963 @default.
• W2792901908 cites W3023775830 @default.
• W2792901908 doi "https://doi.org/10.1186/s12931-018-0727-x" @default.
• W2792901908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5809953" @default.
• W2792901908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29433520" @default.
• W2792901908 hasPublicationYear "2018" @default.
• W2792901908 type Work @default.
• W2792901908 sameAs 2792901908 @default.
• W2792901908 citedByCount "64" @default.
• W2792901908 countsByYear W27929019082018 @default.
• W2792901908 countsByYear W27929019082019 @default.
• W2792901908 countsByYear W27929019082020 @default.
• W2792901908 countsByYear W27929019082021 @default.
• W2792901908 countsByYear W27929019082022 @default.
• W2792901908 countsByYear W27929019082023 @default.
• W2792901908 crossrefType "journal-article" @default.
• W2792901908 hasAuthorship W2792901908A5000323703 @default.
• W2792901908 hasAuthorship W2792901908A5013596240 @default.
• W2792901908 hasAuthorship W2792901908A5022825628 @default.
• W2792901908 hasAuthorship W2792901908A5024648164 @default.
• W2792901908 hasAuthorship W2792901908A5045492083 @default.
• W2792901908 hasAuthorship W2792901908A5054235872 @default.
• W2792901908 hasAuthorship W2792901908A5064692183 @default.
• W2792901908 hasAuthorship W2792901908A5070808341 @default.
• W2792901908 hasAuthorship W2792901908A5076782425 @default.
• W2792901908 hasAuthorship W2792901908A5090340144 @default.
• W2792901908 hasBestOaLocation W27929019081 @default.
• W2792901908 hasConcept C121608353 @default.
• W2792901908 hasConcept C126322002 @default.
• W2792901908 hasConcept C134018914 @default.
• W2792901908 hasConcept C142724271 @default.
• W2792901908 hasConcept C178790620 @default.

• next