FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792944514> ?p ?o ?g. }

• W2792944514 abstract "Physiological activity in healthy conditions requires a coordinated interaction between the molecular circadian clock and the network of biochemical pathways. An important metabolic parameter in the interface between these two entities is the redox state. Among the redox coenzymes that regulate the fluxes of enzymatic reactions is the NADP+/NADPH pair. Indeed, the main biosynthetic pathways need NADPH to serve as an electron donor for cellular anabolic transformations. The existence of a metabolic circadian clock is well established, and it was first identified in mammalian red blood cells. The metabolic circadian clock is independent of transcriptional activity and is sustained by the enzymatic complex peroxiredoxin/thioredoxin/NADPH. This complex shows 24-h redox fluctuations metabolizing H2O2 in various tissues and species (fungi, insects, and mammals). Although this NADPH-sensitive metabolic clock is autonomous in erythrocytes that lack a nucleus, it functions in concert with the transcriptional circadian clock in other cell types to accomplish the task of timing cellular physiology. During carcinogenesis, circadian alterations influence cell cycle onset and promote tumoral growth. These alterations also deregulate cellular energetics through a process known as aerobic glycolysis, or the Warburg effect. The Warburg effect is a typical response of cancer cells in which the metabolism turns into glycolysis even in the presence of functional mitochondria. This alteration has been interpreted as a cellular strategy to increase biomass during cancer, and one of its main factors is the availability of NADPH. This minireview explores the potential role of NADPH as a circadian and cancer-promoting metabolite." @default.
• W2792944514 created "2018-03-29" @default.
• W2792944514 creator A5003722780 @default.
• W2792944514 creator A5062790055 @default.
• W2792944514 date "2018-03-15" @default.
• W2792944514 modified "2023-10-18" @default.
• W2792944514 title "Circadian and Metabolic Perspectives in the Role Played by NADPH in Cancer" @default.
• W2792944514 cites W1865957711 @default.
• W2792944514 cites W1895114046 @default.
• W2792944514 cites W1915639647 @default.
• W2792944514 cites W1970554352 @default.
• W2792944514 cites W1976632546 @default.
• W2792944514 cites W1978260286 @default.
• W2792944514 cites W1981868577 @default.
• W2792944514 cites W1999523233 @default.
• W2792944514 cites W2006966606 @default.
• W2792944514 cites W2014880757 @default.
• W2792944514 cites W2018257401 @default.
• W2792944514 cites W2024399152 @default.
• W2792944514 cites W2026225426 @default.
• W2792944514 cites W2034269086 @default.
• W2792944514 cites W2043195072 @default.
• W2792944514 cites W2045427681 @default.
• W2792944514 cites W2046575171 @default.
• W2792944514 cites W2053243600 @default.
• W2792944514 cites W2078655231 @default.
• W2792944514 cites W2092129257 @default.
• W2792944514 cites W2105829321 @default.
• W2792944514 cites W2117692326 @default.
• W2792944514 cites W2128560714 @default.
• W2792944514 cites W2154692564 @default.
• W2792944514 cites W2158229562 @default.
• W2792944514 cites W2167636534 @default.
• W2792944514 cites W2169542960 @default.
• W2792944514 cites W2180511011 @default.
• W2792944514 cites W2415032283 @default.
• W2792944514 cites W2435365468 @default.
• W2792944514 cites W2494508624 @default.
• W2792944514 cites W2512293483 @default.
• W2792944514 cites W2520881175 @default.
• W2792944514 cites W2605935632 @default.
• W2792944514 cites W2607240486 @default.
• W2792944514 cites W2617996552 @default.
• W2792944514 cites W2619318134 @default.
• W2792944514 cites W2621156215 @default.
• W2792944514 cites W2763898275 @default.
• W2792944514 cites W2770955494 @default.
• W2792944514 doi "https://doi.org/10.3389/fendo.2018.00093" @default.
• W2792944514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5862808" @default.
• W2792944514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29599747" @default.
• W2792944514 hasPublicationYear "2018" @default.
• W2792944514 type Work @default.
• W2792944514 sameAs 2792944514 @default.
• W2792944514 citedByCount "6" @default.
• W2792944514 countsByYear W27929445142019 @default.
• W2792944514 countsByYear W27929445142020 @default.
• W2792944514 countsByYear W27929445142021 @default.
• W2792944514 countsByYear W27929445142022 @default.
• W2792944514 crossrefType "journal-article" @default.
• W2792944514 hasAuthorship W2792944514A5003722780 @default.
• W2792944514 hasAuthorship W2792944514A5062790055 @default.
• W2792944514 hasBestOaLocation W27929445141 @default.
• W2792944514 hasConcept C104317684 @default.
• W2792944514 hasConcept C119599485 @default.
• W2792944514 hasConcept C121446783 @default.
• W2792944514 hasConcept C121608353 @default.
• W2792944514 hasConcept C127413603 @default.
• W2792944514 hasConcept C134018914 @default.
• W2792944514 hasConcept C134146338 @default.
• W2792944514 hasConcept C137059387 @default.
• W2792944514 hasConcept C192989942 @default.
• W2792944514 hasConcept C20251656 @default.
• W2792944514 hasConcept C2778182565 @default.
• W2792944514 hasConcept C28859421 @default.
• W2792944514 hasConcept C38606739 @default.
• W2792944514 hasConcept C42196554 @default.
• W2792944514 hasConcept C54355233 @default.
• W2792944514 hasConcept C55493867 @default.
• W2792944514 hasConcept C555283112 @default.
• W2792944514 hasConcept C62231903 @default.
• W2792944514 hasConcept C86803240 @default.
• W2792944514 hasConcept C95444343 @default.
• W2792944514 hasConcept C96232424 @default.
• W2792944514 hasConceptScore W2792944514C104317684 @default.
• W2792944514 hasConceptScore W2792944514C119599485 @default.
• W2792944514 hasConceptScore W2792944514C121446783 @default.
• W2792944514 hasConceptScore W2792944514C121608353 @default.
• W2792944514 hasConceptScore W2792944514C127413603 @default.
• W2792944514 hasConceptScore W2792944514C134018914 @default.
• W2792944514 hasConceptScore W2792944514C134146338 @default.
• W2792944514 hasConceptScore W2792944514C137059387 @default.
• W2792944514 hasConceptScore W2792944514C192989942 @default.
• W2792944514 hasConceptScore W2792944514C20251656 @default.
• W2792944514 hasConceptScore W2792944514C2778182565 @default.
• W2792944514 hasConceptScore W2792944514C28859421 @default.
• W2792944514 hasConceptScore W2792944514C38606739 @default.
• W2792944514 hasConceptScore W2792944514C42196554 @default.
• W2792944514 hasConceptScore W2792944514C54355233 @default.
• W2792944514 hasConceptScore W2792944514C55493867 @default.
• W2792944514 hasConceptScore W2792944514C555283112 @default.

• next