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- W2792989984 abstract "Although aneuploidy is poorly tolerated during embryogenesis, aneuploidy and whole chromosomal instability (CIN) are common hallmarks of cancer, raising the question of how cancer cells can thrive in spite of chromosome aberrations. Here we present a comprehensive and quantitative proteomics analysis of isogenic DLD-1 colorectal adenocarcinoma cells lines, aimed at identifying cellular responses to changes in ploidy and/or CIN. Specifically, we compared diploid (2N) and tetraploid (4N) cells with posttetraploid aneuploid (PTA) clones and engineered trisomic clones. Our study provides a comparative data set on the proteomes and phosphoproteomes of the above cell lines, comprising several thousand proteins and phosphopeptides. In comparison to the parental 2N line, we observed changes in proteins associated with stress responses and with interferon signaling. Although we did not detect a conspicuous protein signature associated with CIN, we observed many changes in phosphopeptides that relate to fundamental cellular processes, including mitotic progression and spindle function. Most importantly, we found that most changes detectable in PTA cells were already present in the 4N progenitor line. This suggests that activation of mitotic pathways through hyper-phosphorylation likely constitutes an important response to chromosomal burden. In line with this conclusion, cells with extensive chromosome gains showed differential sensitivity toward a number of inhibitors targeting cell cycle kinases, suggesting that the efficacy of anti-mitotic drugs may depend on the karyotype of cancer cells." @default.
- W2792989984 created "2018-03-29" @default.
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- W2792989984 date "2018-05-01" @default.
- W2792989984 modified "2023-10-12" @default.
- W2792989984 title "Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability" @default.
- W2792989984 cites W1521031009 @default.
- W2792989984 cites W1558701786 @default.
- W2792989984 cites W1885700106 @default.
- W2792989984 cites W1920350377 @default.
- W2792989984 cites W1963774361 @default.
- W2792989984 cites W1966669440 @default.
- W2792989984 cites W1970916591 @default.
- W2792989984 cites W1971013077 @default.
- W2792989984 cites W1971204916 @default.
- W2792989984 cites W1971740148 @default.
- W2792989984 cites W1976445111 @default.
- W2792989984 cites W1978302017 @default.
- W2792989984 cites W1987908519 @default.
- W2792989984 cites W1994213227 @default.
- W2792989984 cites W1996152576 @default.
- W2792989984 cites W2000403772 @default.
- W2792989984 cites W2002246796 @default.
- W2792989984 cites W2004599241 @default.
- W2792989984 cites W2006141070 @default.
- W2792989984 cites W2010749771 @default.
- W2792989984 cites W2015556811 @default.
- W2792989984 cites W2016661249 @default.
- W2792989984 cites W2022397091 @default.
- W2792989984 cites W2022527641 @default.
- W2792989984 cites W2026589725 @default.
- W2792989984 cites W2028666395 @default.
- W2792989984 cites W2030086669 @default.
- W2792989984 cites W2032780125 @default.
- W2792989984 cites W2037404897 @default.
- W2792989984 cites W2042146481 @default.
- W2792989984 cites W2043325874 @default.
- W2792989984 cites W2047687247 @default.
- W2792989984 cites W2048280438 @default.
- W2792989984 cites W2049598386 @default.
- W2792989984 cites W2051603299 @default.
- W2792989984 cites W2060082769 @default.
- W2792989984 cites W2060714341 @default.
- W2792989984 cites W2062214822 @default.
- W2792989984 cites W2064358122 @default.
- W2792989984 cites W2064575766 @default.
- W2792989984 cites W2065455422 @default.
- W2792989984 cites W2067708830 @default.
- W2792989984 cites W2074548008 @default.
- W2792989984 cites W2075387573 @default.
- W2792989984 cites W2075601868 @default.
- W2792989984 cites W2076324577 @default.
- W2792989984 cites W2076452392 @default.
- W2792989984 cites W2080308138 @default.
- W2792989984 cites W2081278227 @default.
- W2792989984 cites W2087640484 @default.
- W2792989984 cites W2089353165 @default.
- W2792989984 cites W2095617425 @default.
- W2792989984 cites W2102502996 @default.
- W2792989984 cites W2102922697 @default.
- W2792989984 cites W2103017472 @default.
- W2792989984 cites W2107702258 @default.
- W2792989984 cites W2113662093 @default.
- W2792989984 cites W2113674897 @default.
- W2792989984 cites W2117391334 @default.
- W2792989984 cites W2117692326 @default.
- W2792989984 cites W2120024428 @default.
- W2792989984 cites W2122077019 @default.
- W2792989984 cites W2122382992 @default.
- W2792989984 cites W2123618943 @default.
- W2792989984 cites W2129763268 @default.
- W2792989984 cites W2132178765 @default.
- W2792989984 cites W2133646845 @default.
- W2792989984 cites W2134435289 @default.
- W2792989984 cites W2137220794 @default.
- W2792989984 cites W2138968849 @default.
- W2792989984 cites W2140159547 @default.
- W2792989984 cites W2141444873 @default.
- W2792989984 cites W2154603906 @default.
- W2792989984 cites W2155564780 @default.
- W2792989984 cites W2156372413 @default.
- W2792989984 cites W2159536530 @default.
- W2792989984 cites W2161253116 @default.
- W2792989984 cites W2163390166 @default.
- W2792989984 cites W2164707361 @default.
- W2792989984 cites W2166956439 @default.
- W2792989984 cites W2168270559 @default.
- W2792989984 cites W2229713222 @default.
- W2792989984 cites W2252477019 @default.