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• W2793010596 abstract "Development of drugs for new and persistent diseases will increasingly rely on the expansion of accessible chemical space to allow exploration of novel molecular targets. Here we report the synthesis of a library of novel fused heterobicyclic small molecules based on the 1,4-diazepine and 2,4-pyrrolidinedione scaffolds. Key chemical transformations included a Mannich-type condensation and chemoselective N-acylation reactions. Screening shows anti-cancer activity of several library compounds which suggests translational potential of this novel chemical scaffold." @default.
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• W2793010596 date "2018-04-01" @default.
• W2793010596 modified "2023-10-12" @default.
• W2793010596 title "Synthesis of a novel fused pyrrolodiazepine-based library with anti-cancer activity" @default.
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• W2793010596 doi "https://doi.org/10.1016/j.tetlet.2018.03.021" @default.
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