Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793011605> ?p ?o ?g. }
- W2793011605 endingPage "195" @default.
- W2793011605 startingPage "186" @default.
- W2793011605 abstract "Summary Macrophages are extremely heterogeneous and plastic cells with an important role not only in physiological conditions, but also during inflammation (both for initiation and resolution). In the early 1990s, two different phenotypes of macrophages were described: one of them called classically activated (or inflammatory) macrophages (M1) and the other alternatively activated (or wound‐healing) macrophages (M2). Currently, it is known that functional polarization of macrophages into only two groups is an over‐simplified description of macrophage heterogeneity and plasticity; indeed, it is necessary to consider a continuum of functional states. Overall, the current available data indicate that macrophage polarization is a multifactorial process in which a huge number of factors can be involved producing different activation scenarios. Once a macrophage adopts a phenotype, it still retains the ability to continue changing in response to new environmental influences. The reversibility of polarization has a critical therapeutic value, especially in diseases in which an M1/M2 imbalance plays a pathogenic role. In this review, we assess the high plasticity of macrophages and their potential to be exploited to reduce chronic/detrimental inflammation. On the whole, the evidence detailed in this review underscores macrophage polarization as a target of interest for immunotherapy ." @default.
- W2793011605 created "2018-03-29" @default.
- W2793011605 creator A5013824483 @default.
- W2793011605 creator A5043445598 @default.
- W2793011605 creator A5045446127 @default.
- W2793011605 creator A5057504315 @default.
- W2793011605 date "2018-03-08" @default.
- W2793011605 modified "2023-10-14" @default.
- W2793011605 title "Implications of macrophage polarization in autoimmunity" @default.
- W2793011605 cites W1510474190 @default.
- W2793011605 cites W1518095394 @default.
- W2793011605 cites W1560380872 @default.
- W2793011605 cites W1594268419 @default.
- W2793011605 cites W1784535584 @default.
- W2793011605 cites W1874466605 @default.
- W2793011605 cites W1881636432 @default.
- W2793011605 cites W1892230621 @default.
- W2793011605 cites W1962869168 @default.
- W2793011605 cites W1966033287 @default.
- W2793011605 cites W1967369695 @default.
- W2793011605 cites W1968675231 @default.
- W2793011605 cites W1969257702 @default.
- W2793011605 cites W1977083682 @default.
- W2793011605 cites W1977179270 @default.
- W2793011605 cites W1981253971 @default.
- W2793011605 cites W1984163570 @default.
- W2793011605 cites W1984574450 @default.
- W2793011605 cites W1985859986 @default.
- W2793011605 cites W1986736465 @default.
- W2793011605 cites W1990488806 @default.
- W2793011605 cites W1994840834 @default.
- W2793011605 cites W1998752508 @default.
- W2793011605 cites W2005505978 @default.
- W2793011605 cites W2006521244 @default.
- W2793011605 cites W2007954089 @default.
- W2793011605 cites W2011859476 @default.
- W2793011605 cites W2016868307 @default.
- W2793011605 cites W2019954526 @default.
- W2793011605 cites W2027065592 @default.
- W2793011605 cites W2027768860 @default.
- W2793011605 cites W2028370526 @default.
- W2793011605 cites W2031170043 @default.
- W2793011605 cites W2032639324 @default.
- W2793011605 cites W2032751141 @default.
- W2793011605 cites W2034675295 @default.
- W2793011605 cites W2035609346 @default.
- W2793011605 cites W2038122919 @default.
- W2793011605 cites W2038458001 @default.
- W2793011605 cites W2046935888 @default.
- W2793011605 cites W2053713912 @default.
- W2793011605 cites W2054472394 @default.
- W2793011605 cites W2054540776 @default.
- W2793011605 cites W2058100343 @default.
- W2793011605 cites W2060672294 @default.
- W2793011605 cites W2061545951 @default.
- W2793011605 cites W2065210647 @default.
- W2793011605 cites W2065869173 @default.
- W2793011605 cites W2065930754 @default.
- W2793011605 cites W2071430851 @default.
- W2793011605 cites W2073393820 @default.
- W2793011605 cites W2076833412 @default.
- W2793011605 cites W2077730362 @default.
- W2793011605 cites W2081741824 @default.
- W2793011605 cites W2081810806 @default.
- W2793011605 cites W2083415995 @default.
- W2793011605 cites W2089573422 @default.
- W2793011605 cites W2093705034 @default.
- W2793011605 cites W2099361532 @default.
- W2793011605 cites W2100128950 @default.
- W2793011605 cites W2107927699 @default.
- W2793011605 cites W2110720586 @default.
- W2793011605 cites W2113580903 @default.
- W2793011605 cites W2121438383 @default.
- W2793011605 cites W2123640179 @default.
- W2793011605 cites W2124433916 @default.
- W2793011605 cites W2127898787 @default.
- W2793011605 cites W2128627731 @default.
- W2793011605 cites W2134422149 @default.
- W2793011605 cites W2136188258 @default.
- W2793011605 cites W2140380746 @default.
- W2793011605 cites W2143043043 @default.
- W2793011605 cites W2144741217 @default.
- W2793011605 cites W2145697808 @default.
- W2793011605 cites W2145740221 @default.
- W2793011605 cites W2146921697 @default.
- W2793011605 cites W2156674853 @default.
- W2793011605 cites W2159560463 @default.
- W2793011605 cites W2160797680 @default.
- W2793011605 cites W2162166699 @default.
- W2793011605 cites W2163175900 @default.
- W2793011605 cites W2165866678 @default.
- W2793011605 cites W2165892104 @default.
- W2793011605 cites W2166010463 @default.
- W2793011605 cites W2167354866 @default.
- W2793011605 cites W2167485774 @default.
- W2793011605 cites W2167760404 @default.
- W2793011605 cites W2169616733 @default.
- W2793011605 cites W2182737623 @default.