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- W2793012905 abstract "Abstract Polo-like kinase 1 (Plk1) is a protein kinase currently considered as an attractive cancer target due to its critical role in the cell division cycle. Plk1 is overexpressed in a wide spectrum of human tumors, being frequently considered as an oncogene. However, its contribution to tumor development is unclear. Using a new inducible knock-in mouse model we report here that Plk1 overexpression does not favor cell proliferation but rather results in abnormal chromosome segregation and cytokinesis, leading to the formation of polyploid cells with reduced proliferative potential. Mechanistically, these cytokinesis defects correlate with defective loading of Cep55 and ESCRT complexes to the abscission bridge during cytokinesis in a Plk1 kinase-dependent manner. In vivo, elevated levels of Plk1 markedly prevent the development of mammary gland tumors induced either by Kras G12D or Her2, in the presence of increased rates of chromosome instability. In patients, higher Plk1 expression levels are associated with significantly increased overall survival in breast cancer subtypes. These data suggest that, despite the therapeutic benefits of inhibiting Plk1 due to its essential role in tumor cell cycles, Plk1 overexpression has tumor suppressive properties by perturbing mitotic progression and cytokinesis." @default.
- W2793012905 created "2018-03-29" @default.
- W2793012905 creator A5005882035 @default.
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- W2793012905 creator A5087930016 @default.
- W2793012905 creator A5089532176 @default.
- W2793012905 date "2018-03-20" @default.
- W2793012905 modified "2023-09-27" @default.
- W2793012905 title "Plk1 overexpression suppresses tumor development by inducing chromosomal instability" @default.
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- W2793012905 doi "https://doi.org/10.1101/285635" @default.
- W2793012905 hasPublicationYear "2018" @default.