FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793013002> ?p ?o ?g. }

• W2793013002 endingPage "1368" @default.
• W2793013002 startingPage "1357" @default.
• W2793013002 abstract "Stomatin‐like protein 2 ( STOML 2 or SLP ‐2) is an oncogenic anti‐apoptotic protein that is upregulated in several types of cancer, including cervical cancer. However, the mechanisms responsible for the SLP ‐2 anti‐apoptotic function remain poorly understood. Here, we show that si RNA ‐mediated SLP ‐2 suppression decreases growth of human cervical cancer HELA and SIHA cells, and increases cisplatin‐induced apoptosis through activation of MEK / ERK signaling and suppression of the mitochondrial pathway. The inhibition of the mitochondrial pathway is mediated by increasing the mitochondrial Ca 2+ concentration and mitochondrial membrane potential, thereby downregulating p‐ MEK and p‐ ERK levels, upregulating the Bax/Bcl‐2 ratio, increasing cytochrome C release from mitochondria into the cytosol, and upregulating levels of cleaved‐caspase 9, cleaved‐caspase 3, and cleaved poly ADP‐ribose polymerase (PARP). Overexpression of SLP ‐2 using adenovirus‐ STOML 2 has the opposite effect: it upregulates p‐ MEK and p‐ ERK and downregulates the Bax/Bcl‐2 ratio and levels of cleaved‐caspase 9 to caspase 9, cleaved‐caspase 3 to caspase 3, and cleaved‐ PARP to PARP in cisplatin‐treated cells. These data show that SLP ‐2 inhibits cisplatin‐induced apoptosis by activating the MEK / ERK signaling and inhibiting the mitochondrial apoptosis pathway in cervical cancer cells." @default.
• W2793013002 created "2018-03-29" @default.
• W2793013002 creator A5005109711 @default.
• W2793013002 creator A5064720631 @default.
• W2793013002 creator A5070677531 @default.
• W2793013002 creator A5074232452 @default.
• W2793013002 creator A5080308075 @default.
• W2793013002 creator A5081002875 @default.
• W2793013002 creator A5086908934 @default.
• W2793013002 date "2018-04-24" @default.
• W2793013002 modified "2023-09-25" @default.
• W2793013002 title "Stomatin‐like protein 2 inhibits cisplatin‐induced apoptosis through MEK/ERK signaling and the mitochondrial apoptosis pathway in cervical cancer cells" @default.
• W2793013002 cites W1535444616 @default.
• W2793013002 cites W1542412714 @default.
• W2793013002 cites W1599277155 @default.
• W2793013002 cites W1650009710 @default.
• W2793013002 cites W1965186367 @default.
• W2793013002 cites W1979141644 @default.
• W2793013002 cites W1982868234 @default.
• W2793013002 cites W1992207122 @default.
• W2793013002 cites W1992885568 @default.
• W2793013002 cites W2000535878 @default.
• W2793013002 cites W2021713644 @default.
• W2793013002 cites W2021942889 @default.
• W2793013002 cites W2023437839 @default.
• W2793013002 cites W2035487593 @default.
• W2793013002 cites W2039817035 @default.
• W2793013002 cites W2041586000 @default.
• W2793013002 cites W2047051937 @default.
• W2793013002 cites W2052908553 @default.
• W2793013002 cites W2064080426 @default.
• W2793013002 cites W2075509954 @default.
• W2793013002 cites W2077307563 @default.
• W2793013002 cites W2088087092 @default.
• W2793013002 cites W2100428387 @default.
• W2793013002 cites W2122223062 @default.
• W2793013002 cites W2130106722 @default.
• W2793013002 cites W2144319052 @default.
• W2793013002 cites W2150419742 @default.
• W2793013002 cites W2312395443 @default.
• W2793013002 cites W2331692240 @default.
• W2793013002 doi "https://doi.org/10.1111/cas.13563" @default.
• W2793013002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5980381" @default.
• W2793013002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29516570" @default.
• W2793013002 hasPublicationYear "2018" @default.
• W2793013002 type Work @default.
• W2793013002 sameAs 2793013002 @default.
• W2793013002 citedByCount "26" @default.
• W2793013002 countsByYear W27930130022018 @default.
• W2793013002 countsByYear W27930130022019 @default.
• W2793013002 countsByYear W27930130022020 @default.
• W2793013002 countsByYear W27930130022021 @default.
• W2793013002 countsByYear W27930130022022 @default.
• W2793013002 countsByYear W27930130022023 @default.
• W2793013002 crossrefType "journal-article" @default.
• W2793013002 hasAuthorship W2793013002A5005109711 @default.
• W2793013002 hasAuthorship W2793013002A5064720631 @default.
• W2793013002 hasAuthorship W2793013002A5070677531 @default.
• W2793013002 hasAuthorship W2793013002A5074232452 @default.
• W2793013002 hasAuthorship W2793013002A5080308075 @default.
• W2793013002 hasAuthorship W2793013002A5081002875 @default.
• W2793013002 hasAuthorship W2793013002A5086908934 @default.
• W2793013002 hasBestOaLocation W27930130021 @default.
• W2793013002 hasConcept C104317684 @default.
• W2793013002 hasConcept C121608353 @default.
• W2793013002 hasConcept C127561419 @default.
• W2793013002 hasConcept C1491633281 @default.
• W2793013002 hasConcept C153911025 @default.
• W2793013002 hasConcept C182979987 @default.
• W2793013002 hasConcept C185592680 @default.
• W2793013002 hasConcept C190283241 @default.
• W2793013002 hasConcept C2776694085 @default.
• W2793013002 hasConcept C2777366897 @default.
• W2793013002 hasConcept C2778239845 @default.
• W2793013002 hasConcept C28859421 @default.
• W2793013002 hasConcept C29311851 @default.
• W2793013002 hasConcept C31573885 @default.
• W2793013002 hasConcept C502942594 @default.
• W2793013002 hasConcept C54355233 @default.
• W2793013002 hasConcept C552990157 @default.
• W2793013002 hasConcept C55493867 @default.
• W2793013002 hasConcept C57074206 @default.
• W2793013002 hasConcept C62478195 @default.
• W2793013002 hasConcept C82381507 @default.
• W2793013002 hasConcept C86803240 @default.
• W2793013002 hasConcept C95444343 @default.
• W2793013002 hasConcept C96232424 @default.
• W2793013002 hasConcept C98424977 @default.
• W2793013002 hasConceptScore W2793013002C104317684 @default.
• W2793013002 hasConceptScore W2793013002C121608353 @default.
• W2793013002 hasConceptScore W2793013002C127561419 @default.
• W2793013002 hasConceptScore W2793013002C1491633281 @default.
• W2793013002 hasConceptScore W2793013002C153911025 @default.
• W2793013002 hasConceptScore W2793013002C182979987 @default.
• W2793013002 hasConceptScore W2793013002C185592680 @default.
• W2793013002 hasConceptScore W2793013002C190283241 @default.
• W2793013002 hasConceptScore W2793013002C2776694085 @default.
• W2793013002 hasConceptScore W2793013002C2777366897 @default.

• next