Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793072040> ?p ?o ?g. }
- W2793072040 abstract "Abstract Adult stem cells persist in mammalian tissues by entering a state of reversible arrest or quiescence associated with low transcription. Using cultured myoblasts and primary muscle stem cells, we show that RNA synthesis is strongly repressed in G 0 , returning within minutes of activation. We investigate the underlying mechanism and reveal a role for promoter-proximal RNAPol II pausing: by mapping global Pol II occupancy using ChIP-seq, in conjunction with RNA-seq to identify repressed transcriptional networks unique to G 0 . Strikingly, Pol II pausing is enhanced in G 0 on genes encoding regulators of RNA biogenesis (Ncl, Rps24, Ctdp1), and release of pausing is critical for cell cycle re-entry. Finally, we uncover a novel, unexpected repressive role of the super-elongation complex component Aff4 in G 0 -specific stalling. We propose a model wherein Pol II pausing restrains transcription to maintain G 0 , preconfigures gene networks required for the G 0 -G 1 transition, and sets the timing of their transcriptional activation." @default.
- W2793072040 created "2018-03-29" @default.
- W2793072040 creator A5014243795 @default.
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- W2793072040 creator A5042746540 @default.
- W2793072040 creator A5073296627 @default.
- W2793072040 date "2018-01-19" @default.
- W2793072040 modified "2023-09-24" @default.
- W2793072040 title "RNA polymerase II pausing regulates a quiescence-dependent transcriptional program, priming cells for cell cycle reentry" @default.
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- W2793072040 doi "https://doi.org/10.1101/250910" @default.
- W2793072040 hasPublicationYear "2018" @default.