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- W2793104920 abstract "In Brief The patient is a 57-year-old man with liver cirrhosis, Bricker anastomosis after a radical cystoprostatectomy and, a history of bacteremias caused by extended-spectrum β-lactamase–positive Escherichia coli, Enterococcus faecium, and Candida albicans. He presented with persistent low back pain and was diagnosed with vertebral osteomyelitis, for which he received ertapenem-linezolid treatment. However, after 20 days, linezolid had to be discontinued because of myelotoxicity and metabolic acidosis. The patient was switched to tedizolid, which, in combination with ertapenem, was successfully given for 114 days until biopsy showed no growth of gram-positive cocci. We conclude that tedizolid can be an alternative to linezolid in case of toxicity, especially in long-term treatments. Clinical trials do not collect rare pathologies or etiologies and exclude complex patients, so clinicians do not have evidence in these cases, and published experience helps in decision-making. The authors present the case of a patient with advanced cirrhosis with spondylodiscitis secondary to resistant germs secondary to a complex postoperative course in which treatment with tedizolid was well tolerated in the long term compared to the initial linezolid option." @default.
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- W2793104920 date "2018-11-01" @default.
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- W2793104920 title "Long-Term Safety of Tedizolid in a Patient With Spondilodiscitis After Switch From Linezolid Due to Toxicity" @default.
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- W2793104920 doi "https://doi.org/10.1097/ipc.0000000000000623" @default.
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