Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793118529> ?p ?o ?g. }
- W2793118529 abstract "Stenotrophomonas maltophilia is an emerging nosocomial pathogen with high resistance to most clinically used antimicrobials. Tigecycline is a potential alternative antimicrobial for S. maltophilia infection treatment, but its resistance mechanism in clinical isolates is not fully elucidated. We investigated the antimicrobial susceptibility of 450 S. maltophilia isolated during 2012–2015 from three university hospitals in Beijing, China. These strains exhibited high susceptibility to minocycline (98.44%), sulfamethoxazole/trimethoprim (87.56%), tigecycline (77.78 %), doxycycline (81.33%), levofloxacin (67.56%) and ticarcillin/clavulanate (73.00%). The susceptibility of tigecycline-nonsusceptible strains (TNS) to doxycycline and levofloxacin was much lower than that of tigecycline-susceptible strains (TSS) (25.00% vs. 97.71% for doxycycline, P < 0.001; 17.00% vs. 82.00% for levofloxacin, P < 0.001). We further selected 48 TNS and TSS and compared the detection rate of eight tetracycline-specific genes by PCR and the expression level of six intrinsic multidrug resistance efflux pumps by real-time PCR. Only one tetB and two tetH genes in TNS and three tetH genes in TSS were detected, and the detection rate had no difference. The average expression level of smeD in TNS was higher than that in TSS [20.59 (11.53, 112.54) vs. 2.07 (0.80, 4.96), P < 0.001], while the average expression levels of smeA, smeI, smeO, smeV, and smrA were not significantly different, indicating that smeDEF was the predominant resistance genetic determinant in clinical S. maltophilia. Higher smeD expression was also observed in levofloxacin- and doxycycline-nonsusceptible isolates than in their corresponding susceptible isolates [16.46 (5.83, 102.24) vs. 2.72 (0.80, 6.25) for doxycycline, P < 0.001; 19.69 (8.07, 115.10) vs. 3.01(1.00, 6.03), P < 0.001], indicating that smeDEF was also the resistance genetic determinant to levofloxacin and doxycycline. The consistent resistance profile and common resistance genetic determinant highlight the importance of rational use of tigecycline for preventing the occurrence and spread of multidrug resistance." @default.
- W2793118529 created "2018-03-29" @default.
- W2793118529 creator A5008659449 @default.
- W2793118529 creator A5011877804 @default.
- W2793118529 creator A5035280226 @default.
- W2793118529 creator A5039561937 @default.
- W2793118529 creator A5062632432 @default.
- W2793118529 creator A5070812231 @default.
- W2793118529 creator A5074666857 @default.
- W2793118529 creator A5082388816 @default.
- W2793118529 date "2018-03-26" @default.
- W2793118529 modified "2023-10-18" @default.
- W2793118529 title "Frequency and Genetic Determinants of Tigecycline Resistance in Clinically Isolated Stenotrophomonas maltophilia in Beijing, China" @default.
- W2793118529 cites W1519230005 @default.
- W2793118529 cites W1718912930 @default.
- W2793118529 cites W1851388668 @default.
- W2793118529 cites W1921056904 @default.
- W2793118529 cites W1965317531 @default.
- W2793118529 cites W1968014038 @default.
- W2793118529 cites W1968992276 @default.
- W2793118529 cites W1975438923 @default.
- W2793118529 cites W1975868175 @default.
- W2793118529 cites W1980565095 @default.
- W2793118529 cites W1999639190 @default.
- W2793118529 cites W2004250666 @default.
- W2793118529 cites W2007348641 @default.
- W2793118529 cites W2008553807 @default.
- W2793118529 cites W2009359065 @default.
- W2793118529 cites W2009364528 @default.
- W2793118529 cites W2020591349 @default.
- W2793118529 cites W2029529467 @default.
- W2793118529 cites W2039427303 @default.
- W2793118529 cites W2043273831 @default.
- W2793118529 cites W2044784024 @default.
- W2793118529 cites W2045842501 @default.
- W2793118529 cites W2067212901 @default.
- W2793118529 cites W2094747692 @default.
- W2793118529 cites W2100796737 @default.
- W2793118529 cites W2103490150 @default.
- W2793118529 cites W2103575880 @default.
- W2793118529 cites W2118875526 @default.
- W2793118529 cites W2122366225 @default.
- W2793118529 cites W2125173993 @default.
- W2793118529 cites W2139818499 @default.
- W2793118529 cites W2145958601 @default.
- W2793118529 cites W2149103203 @default.
- W2793118529 cites W2152973319 @default.
- W2793118529 cites W2155317724 @default.
- W2793118529 cites W2158918133 @default.
- W2793118529 cites W2163206615 @default.
- W2793118529 cites W2168442812 @default.
- W2793118529 cites W2233094300 @default.
- W2793118529 cites W2305096587 @default.
- W2793118529 cites W2347180060 @default.
- W2793118529 cites W2395537894 @default.
- W2793118529 cites W2429792065 @default.
- W2793118529 cites W2534882781 @default.
- W2793118529 cites W284908474 @default.
- W2793118529 doi "https://doi.org/10.3389/fmicb.2018.00549" @default.
- W2793118529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5879106" @default.
- W2793118529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29632524" @default.
- W2793118529 hasPublicationYear "2018" @default.
- W2793118529 type Work @default.
- W2793118529 sameAs 2793118529 @default.
- W2793118529 citedByCount "24" @default.
- W2793118529 countsByYear W27931185292019 @default.
- W2793118529 countsByYear W27931185292020 @default.
- W2793118529 countsByYear W27931185292021 @default.
- W2793118529 countsByYear W27931185292022 @default.
- W2793118529 countsByYear W27931185292023 @default.
- W2793118529 crossrefType "journal-article" @default.
- W2793118529 hasAuthorship W2793118529A5008659449 @default.
- W2793118529 hasAuthorship W2793118529A5011877804 @default.
- W2793118529 hasAuthorship W2793118529A5035280226 @default.
- W2793118529 hasAuthorship W2793118529A5039561937 @default.
- W2793118529 hasAuthorship W2793118529A5062632432 @default.
- W2793118529 hasAuthorship W2793118529A5070812231 @default.
- W2793118529 hasAuthorship W2793118529A5074666857 @default.
- W2793118529 hasAuthorship W2793118529A5082388816 @default.
- W2793118529 hasBestOaLocation W27931185291 @default.
- W2793118529 hasConcept C133936738 @default.
- W2793118529 hasConcept C200082930 @default.
- W2793118529 hasConcept C2776083883 @default.
- W2793118529 hasConcept C2776352461 @default.
- W2793118529 hasConcept C2777027569 @default.
- W2793118529 hasConcept C2777179404 @default.
- W2793118529 hasConcept C2777637488 @default.
- W2793118529 hasConcept C2778275353 @default.
- W2793118529 hasConcept C2779631663 @default.
- W2793118529 hasConcept C2780923616 @default.
- W2793118529 hasConcept C2781276175 @default.
- W2793118529 hasConcept C4937899 @default.
- W2793118529 hasConcept C501593827 @default.
- W2793118529 hasConcept C523546767 @default.
- W2793118529 hasConcept C54355233 @default.
- W2793118529 hasConcept C86803240 @default.
- W2793118529 hasConcept C89423630 @default.
- W2793118529 hasConcept C94665300 @default.
- W2793118529 hasConceptScore W2793118529C133936738 @default.
- W2793118529 hasConceptScore W2793118529C200082930 @default.