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• W2793127625 abstract "<b><i>Objective:</i></b> To compare the outcome of hepatic arterial infusion chemotherapy combined with radiotherapy (HAIC + RT) versus sorafenib monotherapy in patients with advanced hepatocellular carcinoma (HCC) and major portal vein tumor thrombosis (PVTT). <b><i>Methods:</i></b> This retrospective study included 108 HCC patients with PVTT of the main trunk or first branch and Child-Pugh ≤7. Sixty-eight received HAIC + RT and 40 received sorafenib. Patients were then assigned to the HAIC + RT group (<i>n</i> = 36) and the sorafenib group (<i>n</i> = 36) through case-control matching. The decision to treat with HAIC + RT or sorafenib was left to the attending physician. <b><i>Results:</i></b> The median overall, progression-free, and postprogression survival were significantly longer in the HAIC + RT group than in the sorafenib group (9.9 vs. 5.3, <i>p =</i> 0.002; 3.9 vs. 2.1, <i>p =</i> 0.048; and 3.7 vs. 1.9 months, <i>p =</i> 0.02, respectively). Multivariate analysis identified HAIC + RT (hazard ratio = 2.02; 95% confidence interval, 1.14–3.57; <i>p =</i> 0.01) as a significant and independent determinant of overall survival. <b><i>Conclusions:</i></b> In patients with advanced HCC and major PVTT, survival was significantly longer in those treated with HAIC + RT than with sorafenib." @default.
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• W2793127625 date "2018-01-01" @default.
• W2793127625 modified "2023-10-16" @default.
• W2793127625 title "Comparison of Outcome of Hepatic Arterial Infusion Chemotherapy Combined with Radiotherapy and Sorafenib for Advanced Hepatocellular Carcinoma Patients with Major Portal Vein Tumor Thrombosis" @default.
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• W2793127625 doi "https://doi.org/10.1159/000486483" @default.
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