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• W2793143008 endingPage "91" @default.
• W2793143008 startingPage "86" @default.
• W2793143008 abstract "In the last couple of years, several extended half-life factor VIII and factor IX preparations were intensively studied and gained approval. In order to extend half-lives, techniques like fusion to protein conjugates (Fc part of IgG1 or albumin), chemical modification (PEGylation), and protein sequence modification are implemented. With these techniques, it is possible to extend half-lives of factor IX products 4- to 6- fold, while half-life extension of factor VIII products is limited to 1.5- to 2-fold due to their interaction with von Willebrand factor. Nevertheless, both extended half-life factor VIII and IX products have improved and facilitated prophylactic factor replacement therapy in hemophilia A and B, respectively. Extended half-life factor concentrates pose challenges to coagulation laboratories because accurate therapy monitoring is not possible with all factor activity assays currently used." @default.
• W2793143008 created "2018-03-29" @default.
• W2793143008 creator A5058444329 @default.
• W2793143008 date "2018-01-01" @default.
• W2793143008 modified "2023-10-06" @default.
• W2793143008 title "Extended Half-Life Factor VIII and Factor IX Preparations" @default.
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• W2793143008 doi "https://doi.org/10.1159/000488060" @default.
• W2793143008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5939656" @default.
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• W2793143008 hasPublicationYear "2018" @default.
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