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- W2793185840 abstract "In the late 1990s, the implementation of highly active antiretroviral (ARV) therapies (HAART) dramatically changed the prognosis in vertically acquired human immunodeficiency virus (HIV) infection. ARV-related short- and long-term toxicity in the HIV-exposed uninfected (HEU) infant remains of concern, with hematological and mitochondrial toxicity being the most commonly observed consequences. Newer nucleoside reverse transcriptase inhibitors (NRTIs) show a much lower propensity to cause mitochondrial toxicity. Mitochondrial alterations have long been associated with HIV infection and with ARV drugs in adulthood and children. In the research setting, the pathogenesis of HIV- and HAART-associated mitochondrial dysfunction in HIV-infected patients has been much less studied in children and adolescents compared with adults. Longitudinal studies in large cohorts of mother-to-child transmission (MTCT) HIV-infected children and adolescents are needed to better illuminate mitochondrial toxicity pathways and their clinical significance in the pediatric population." @default.
- W2793185840 created "2018-03-29" @default.
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- W2793185840 date "2018-02-23" @default.
- W2793185840 modified "2023-10-18" @default.
- W2793185840 title "Mitochondrial Toxicity in Children and Adolescents Exposed to Antiretroviral Therapy" @default.
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- W2793185840 doi "https://doi.org/10.1002/9781119329725.ch34" @default.
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