Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793209087> ?p ?o ?g. }
- W2793209087 endingPage "157" @default.
- W2793209087 startingPage "131" @default.
- W2793209087 abstract "Directed evolution is a powerful technique for generating tailor-made enzymes for a wide range of biocatalytic applications. Following the principles of natural evolution, iterative cycles of mutagenesis and screening or selection are applied to modify protein properties, enhance catalytic activities, or develop completely new protein catalysts for non-natural chemical transformations. This review briefly surveys the experimental methods used to generate genetic diversity and screen or select for improved enzyme variants. Emphasis is placed on a key challenge, namely how to generate novel catalytic activities that expand the scope of natural reactions. Two particularly effective strategies, exploiting catalytic promiscuity and rational design, are illustrated by representative examples of successfully evolved enzymes. Opportunities for extending these approaches to more complex biocatalytic systems are also considered." @default.
- W2793209087 created "2018-03-29" @default.
- W2793209087 creator A5044029247 @default.
- W2793209087 creator A5058923797 @default.
- W2793209087 date "2018-06-20" @default.
- W2793209087 modified "2023-10-14" @default.
- W2793209087 title "Directed Evolution of Protein Catalysts" @default.
- W2793209087 cites W1031680929 @default.
- W2793209087 cites W1500888647 @default.
- W2793209087 cites W1510728434 @default.
- W2793209087 cites W1858890890 @default.
- W2793209087 cites W1954202239 @default.
- W2793209087 cites W1965637904 @default.
- W2793209087 cites W1966935274 @default.
- W2793209087 cites W1968400590 @default.
- W2793209087 cites W1969492379 @default.
- W2793209087 cites W1970386034 @default.
- W2793209087 cites W1978754461 @default.
- W2793209087 cites W1979700983 @default.
- W2793209087 cites W1982792504 @default.
- W2793209087 cites W1983186463 @default.
- W2793209087 cites W1984180361 @default.
- W2793209087 cites W1986056153 @default.
- W2793209087 cites W1987587964 @default.
- W2793209087 cites W1987696643 @default.
- W2793209087 cites W1990557050 @default.
- W2793209087 cites W1991618419 @default.
- W2793209087 cites W1993554361 @default.
- W2793209087 cites W1994240720 @default.
- W2793209087 cites W1995528755 @default.
- W2793209087 cites W1995879115 @default.
- W2793209087 cites W1998818153 @default.
- W2793209087 cites W1999691108 @default.
- W2793209087 cites W2002219567 @default.
- W2793209087 cites W2002470296 @default.
- W2793209087 cites W2005501998 @default.
- W2793209087 cites W2005733654 @default.
- W2793209087 cites W2006137883 @default.
- W2793209087 cites W2007796608 @default.
- W2793209087 cites W2008733674 @default.
- W2793209087 cites W2011513747 @default.
- W2793209087 cites W2012457974 @default.
- W2793209087 cites W2012815969 @default.
- W2793209087 cites W2014280607 @default.
- W2793209087 cites W2015449517 @default.
- W2793209087 cites W2017568512 @default.
- W2793209087 cites W2028113659 @default.
- W2793209087 cites W2028578970 @default.
- W2793209087 cites W2029583307 @default.
- W2793209087 cites W2029886517 @default.
- W2793209087 cites W2032479422 @default.
- W2793209087 cites W2033196044 @default.
- W2793209087 cites W2033442130 @default.
- W2793209087 cites W2033969841 @default.
- W2793209087 cites W2037827934 @default.
- W2793209087 cites W2038201483 @default.
- W2793209087 cites W2038408520 @default.
- W2793209087 cites W2042680126 @default.
- W2793209087 cites W2045226520 @default.
- W2793209087 cites W2047893704 @default.
- W2793209087 cites W2051341954 @default.
- W2793209087 cites W2055212608 @default.
- W2793209087 cites W2059671707 @default.
- W2793209087 cites W2060621401 @default.
- W2793209087 cites W2061378257 @default.
- W2793209087 cites W2062275861 @default.
- W2793209087 cites W2062461675 @default.
- W2793209087 cites W2064048414 @default.
- W2793209087 cites W2066381187 @default.
- W2793209087 cites W2067452122 @default.
- W2793209087 cites W2068815648 @default.
- W2793209087 cites W2070268621 @default.
- W2793209087 cites W2070981224 @default.
- W2793209087 cites W2071268710 @default.
- W2793209087 cites W2073914802 @default.
- W2793209087 cites W2075601360 @default.
- W2793209087 cites W2077621515 @default.
- W2793209087 cites W2078531329 @default.
- W2793209087 cites W2079114878 @default.
- W2793209087 cites W2079251921 @default.
- W2793209087 cites W2079347688 @default.
- W2793209087 cites W2081835258 @default.
- W2793209087 cites W2082260955 @default.
- W2793209087 cites W2086462671 @default.
- W2793209087 cites W2086839412 @default.
- W2793209087 cites W2093007308 @default.
- W2793209087 cites W2094478741 @default.
- W2793209087 cites W2095923527 @default.
- W2793209087 cites W2097861808 @default.
- W2793209087 cites W2098840696 @default.
- W2793209087 cites W2099282718 @default.
- W2793209087 cites W2101060473 @default.
- W2793209087 cites W2101700211 @default.
- W2793209087 cites W2103731920 @default.
- W2793209087 cites W2109154110 @default.
- W2793209087 cites W2110260818 @default.
- W2793209087 cites W2115949736 @default.
- W2793209087 cites W2118131251 @default.