Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793209870> ?p ?o ?g. }
- W2793209870 abstract "During Chagas disease, the Trypanosoma cruzi can induce some changes in the host cells in order to escape or manipulate the host immune response. The modulation of the lipid metabolism in the host phagocytes or in the parasite itself is one feature that has been observed. The goal of this mini review is to discuss the mechanisms that regulate intracellular lipid body (LB) biogenesis in the course of this parasite infection and their meaning to the pathophysiology of the disease. The interaction host-parasite induces LB (or lipid droplet) formation in a Toll-like receptor 2-dependent mechanism in macrophages and is enhanced by apoptotic cell uptake. Simultaneously, there is a lipid accumulation in the parasite due to the incorporation of host fatty acids. The increase in the LB accumulation during infection is correlated with an increase in the synthesis of PGE2 within the host cells and the parasite LBs. Moreover, the treatment with fatty acid synthase inhibitor C75 or non-steroidal anti-inflammatory drugs such as NS-398 and aspirin inhibited the LB biogenesis and also induced the down modulation of the eicosanoid production and the parasite replication. These findings show that LBs are organelles up modulated during the course of infection. Furthermore, the biogenesis of the LB is involved in the lipid mediator generation by both the macrophages and the parasite triggering escape mechanisms." @default.
- W2793209870 created "2018-03-29" @default.
- W2793209870 creator A5014032907 @default.
- W2793209870 creator A5022940068 @default.
- W2793209870 creator A5056615754 @default.
- W2793209870 creator A5073311874 @default.
- W2793209870 date "2018-03-20" @default.
- W2793209870 modified "2023-10-18" @default.
- W2793209870 title "Lipid Bodies as Sites of Prostaglandin E2 Synthesis During Chagas Disease: Impact in the Parasite Escape Mechanism" @default.
- W2793209870 cites W1508394416 @default.
- W2793209870 cites W1511119578 @default.
- W2793209870 cites W1550747483 @default.
- W2793209870 cites W1563504345 @default.
- W2793209870 cites W1573103899 @default.
- W2793209870 cites W1594912295 @default.
- W2793209870 cites W1605704109 @default.
- W2793209870 cites W1619437296 @default.
- W2793209870 cites W1647832452 @default.
- W2793209870 cites W1652987014 @default.
- W2793209870 cites W1854421050 @default.
- W2793209870 cites W1945140151 @default.
- W2793209870 cites W1963956807 @default.
- W2793209870 cites W1966383003 @default.
- W2793209870 cites W1968041774 @default.
- W2793209870 cites W1968126541 @default.
- W2793209870 cites W1969989200 @default.
- W2793209870 cites W1971538078 @default.
- W2793209870 cites W1971609759 @default.
- W2793209870 cites W1972424096 @default.
- W2793209870 cites W1979905466 @default.
- W2793209870 cites W1981383459 @default.
- W2793209870 cites W1982419226 @default.
- W2793209870 cites W1989142099 @default.
- W2793209870 cites W1990351735 @default.
- W2793209870 cites W1992581454 @default.
- W2793209870 cites W1996196835 @default.
- W2793209870 cites W1999757699 @default.
- W2793209870 cites W1999898913 @default.
- W2793209870 cites W2001906128 @default.
- W2793209870 cites W2013393635 @default.
- W2793209870 cites W2013623558 @default.
- W2793209870 cites W2015548068 @default.
- W2793209870 cites W2019981157 @default.
- W2793209870 cites W2021728256 @default.
- W2793209870 cites W2029667277 @default.
- W2793209870 cites W2030131475 @default.
- W2793209870 cites W2032261812 @default.
- W2793209870 cites W2041657945 @default.
- W2793209870 cites W2043237666 @default.
- W2793209870 cites W2046333439 @default.
- W2793209870 cites W2046919271 @default.
- W2793209870 cites W2051888070 @default.
- W2793209870 cites W2053097726 @default.
- W2793209870 cites W2055375742 @default.
- W2793209870 cites W2063297728 @default.
- W2793209870 cites W2064056874 @default.
- W2793209870 cites W2064546848 @default.
- W2793209870 cites W2066451384 @default.
- W2793209870 cites W2068845408 @default.
- W2793209870 cites W2071890540 @default.
- W2793209870 cites W2072291193 @default.
- W2793209870 cites W2075575974 @default.
- W2793209870 cites W2079938574 @default.
- W2793209870 cites W2083516615 @default.
- W2793209870 cites W2088988575 @default.
- W2793209870 cites W2091456991 @default.
- W2793209870 cites W2094093571 @default.
- W2793209870 cites W2096961333 @default.
- W2793209870 cites W2103684899 @default.
- W2793209870 cites W2105757310 @default.
- W2793209870 cites W2121253965 @default.
- W2793209870 cites W2124626543 @default.
- W2793209870 cites W2128149258 @default.
- W2793209870 cites W2137074831 @default.
- W2793209870 cites W2141265612 @default.
- W2793209870 cites W2141723796 @default.
- W2793209870 cites W2141780213 @default.
- W2793209870 cites W2145561855 @default.
- W2793209870 cites W2147347287 @default.
- W2793209870 cites W2147963733 @default.
- W2793209870 cites W2149350714 @default.
- W2793209870 cites W2152920085 @default.
- W2793209870 cites W2153708911 @default.
- W2793209870 cites W2156605941 @default.
- W2793209870 cites W2165199797 @default.
- W2793209870 cites W2288165580 @default.
- W2793209870 cites W2341685224 @default.
- W2793209870 cites W2402903496 @default.
- W2793209870 cites W2485412989 @default.
- W2793209870 cites W2560289760 @default.
- W2793209870 cites W2613622888 @default.
- W2793209870 cites W2743619083 @default.
- W2793209870 cites W2755895700 @default.
- W2793209870 cites W2770961549 @default.
- W2793209870 cites W4256096190 @default.
- W2793209870 cites W59509408 @default.
- W2793209870 doi "https://doi.org/10.3389/fmicb.2018.00499" @default.
- W2793209870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5991165" @default.
- W2793209870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29888755" @default.
- W2793209870 hasPublicationYear "2018" @default.