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• W2793232425 endingPage "2151" @default.
• W2793232425 startingPage "2144" @default.
• W2793232425 abstract "Abstract The synthesis of new conazole analogues ( 8 a‐d ) was performed by three steps sequential reactions of compounds 5 a,b containing the condensation with 4‐chlorophenylethanone, reduction of carbonyl function and O‐alkylation intermediates 2‐[(4‐Benzyl‐5‐{[4‐(4‐fluorophenyl)piperazin‐1‐yl]methyl}‐4 H ‐1,2,4‐triazol‐3‐yl)thio]‐1‐(4‐chlorophenyl)ethanol (7 a) and 2‐[(5‐{[4‐(4‐fluorophenyl)piperazin‐1‐yl]methyl}‐4‐phenyl‐4 H ‐1,2,4‐triazol‐3‐yl)thio]‐1‐phenylethanol (7 b) . The treatment of triazoles 4‐Benzyl‐5‐{[4‐(4‐fluorophenyl)piperazin‐1‐yl]methyl}‐2,4‐dihydro‐4 H ‐1,2,4‐triazole‐3‐thiol ( 5 a ) and 5‐{[4‐(4‐Fluorophenyl)piperazin‐1‐yl]methyl}‐4‐phenyl‐4 H ‐1,2,4‐triazole‐3‐thiol ( 5 b ) with several amines in the presence of formaldehyde generated the corresponding Mannich bases ( 9‐12 ). All the reactions were examined under traditional and microwave irradiation conditions, and optimum conditions were defined. The antimicrobial, antiurease and antioxidant activities of the newly synthesized compounds were screened. Most of them had potent activity against to test microorganism. Especially mannich bases showed minimum inhibitory concentration (MIC) values between 0.24 and 1.9 μg/mL." @default.
• W2793232425 created "2018-03-29" @default.
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• W2793232425 date "2018-02-20" @default.
• W2793232425 modified "2023-10-09" @default.
• W2793232425 title "Design, Microwave-Assisted and Conventional Synthesis of New Hybrid Compounds Derived From 1-(4-Fluorophenyl)piperazine and Screening for Their Biological Activities" @default.
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• W2793232425 doi "https://doi.org/10.1002/slct.201800019" @default.
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