Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793264615> ?p ?o ?g. }
- W2793264615 endingPage "204" @default.
- W2793264615 startingPage "196" @default.
- W2793264615 abstract "Methadone is a synthetic, long-acting opioid with a single chiral center forming two enantiomers, (R)-methadone and (S)-methadone, each having specific pharmacological actions. Concentrations of (R)- and (S)-methadone above therapeutic levels have the ability to cause serious, life-threatening, and fatal side effects. This toxicity can be due in part to the pharmacogenetics of an individual, which influences the pharmacokinetic and pharmacodynamic properties of the drug. Methadone is primarily metabolized in the liver by cytochrome P450 (CYP) enzymes, predominately by CYP2B6, followed by CYP3A4, 2C19, 2D6, and to a lesser extent, CYP2C18, 3A7, 2C8, 2C9, 3A5, and 1A2. Single nucleotide polymorphisms (SNPs) located within CYPs have the potential to play an important role in altering methadone metabolism and pharmacodynamics. Several SNPs in the CYP2B6, 3A4, 2C19, 2D6, and 3A5 genes result in increases in methadone plasma concentrations, decreased N-demethylation, and decreased methadone clearance. In particular, carriers of CYP2B6*6/*6 may have a greater risk for detrimental adverse effects, as methadone metabolism and clearance are diminished in these individuals. CYP2B6*4, on the other hand, has been observed to decrease plasma concentrations of methadone due to increased methadone clearance. The involvement, contribution, and understanding the role of SNPs in CYP2B6, and other CYP genes, in methadone metabolism can improve the therapeutic uses of methadone in patient outcome and the development of personalized medicine." @default.
- W2793264615 created "2018-03-29" @default.
- W2793264615 creator A5018878943 @default.
- W2793264615 creator A5026517567 @default.
- W2793264615 creator A5031018440 @default.
- W2793264615 date "2018-07-01" @default.
- W2793264615 modified "2023-10-04" @default.
- W2793264615 title "Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics" @default.
- W2793264615 cites W1494031902 @default.
- W2793264615 cites W1529433275 @default.
- W2793264615 cites W1551826334 @default.
- W2793264615 cites W1554520053 @default.
- W2793264615 cites W1555210154 @default.
- W2793264615 cites W1565736591 @default.
- W2793264615 cites W1565922578 @default.
- W2793264615 cites W1846936944 @default.
- W2793264615 cites W1891090353 @default.
- W2793264615 cites W1971712648 @default.
- W2793264615 cites W1973460885 @default.
- W2793264615 cites W1977624078 @default.
- W2793264615 cites W1979097034 @default.
- W2793264615 cites W1979157320 @default.
- W2793264615 cites W1981644593 @default.
- W2793264615 cites W1985306774 @default.
- W2793264615 cites W1987178620 @default.
- W2793264615 cites W1991226321 @default.
- W2793264615 cites W1994400379 @default.
- W2793264615 cites W1996104441 @default.
- W2793264615 cites W1998034548 @default.
- W2793264615 cites W1998425896 @default.
- W2793264615 cites W2003049082 @default.
- W2793264615 cites W2004075791 @default.
- W2793264615 cites W2010216918 @default.
- W2793264615 cites W2010427019 @default.
- W2793264615 cites W2016485321 @default.
- W2793264615 cites W2019676480 @default.
- W2793264615 cites W2019939029 @default.
- W2793264615 cites W2021011301 @default.
- W2793264615 cites W2021775978 @default.
- W2793264615 cites W2024519384 @default.
- W2793264615 cites W2032191165 @default.
- W2793264615 cites W2052101401 @default.
- W2793264615 cites W2053473429 @default.
- W2793264615 cites W2055927684 @default.
- W2793264615 cites W2059600528 @default.
- W2793264615 cites W2059846399 @default.
- W2793264615 cites W2070536631 @default.
- W2793264615 cites W2080413289 @default.
- W2793264615 cites W2088639396 @default.
- W2793264615 cites W2089203579 @default.
- W2793264615 cites W2089597415 @default.
- W2793264615 cites W2090818825 @default.
- W2793264615 cites W2098325942 @default.
- W2793264615 cites W2102836173 @default.
- W2793264615 cites W2104423611 @default.
- W2793264615 cites W2107000984 @default.
- W2793264615 cites W2108889004 @default.
- W2793264615 cites W2127867423 @default.
- W2793264615 cites W2131319167 @default.
- W2793264615 cites W2136824414 @default.
- W2793264615 cites W2137344954 @default.
- W2793264615 cites W2140003901 @default.
- W2793264615 cites W2140584456 @default.
- W2793264615 cites W2141864821 @default.
- W2793264615 cites W2150194685 @default.
- W2793264615 cites W2150270654 @default.
- W2793264615 cites W2152506996 @default.
- W2793264615 cites W2159677620 @default.
- W2793264615 cites W2162096292 @default.
- W2793264615 cites W2167392727 @default.
- W2793264615 cites W2183254285 @default.
- W2793264615 cites W2188968947 @default.
- W2793264615 cites W2310803930 @default.
- W2793264615 cites W2333750047 @default.
- W2793264615 cites W2338661602 @default.
- W2793264615 cites W2414357051 @default.
- W2793264615 cites W2467610311 @default.
- W2793264615 cites W2467700705 @default.
- W2793264615 cites W2561135550 @default.
- W2793264615 cites W2586776260 @default.
- W2793264615 cites W2605348885 @default.
- W2793264615 cites W2739306877 @default.
- W2793264615 cites W3133237156 @default.
- W2793264615 cites W4211085917 @default.
- W2793264615 cites W4211214267 @default.
- W2793264615 doi "https://doi.org/10.1016/j.bcp.2018.02.020" @default.
- W2793264615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6148365" @default.
- W2793264615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29458047" @default.
- W2793264615 hasPublicationYear "2018" @default.
- W2793264615 type Work @default.
- W2793264615 sameAs 2793264615 @default.
- W2793264615 citedByCount "45" @default.
- W2793264615 countsByYear W27932646152018 @default.
- W2793264615 countsByYear W27932646152019 @default.
- W2793264615 countsByYear W27932646152020 @default.
- W2793264615 countsByYear W27932646152021 @default.
- W2793264615 countsByYear W27932646152022 @default.
- W2793264615 countsByYear W27932646152023 @default.