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• W2793272954 abstract "Abstract Central sleep apnea (CSA) is highly prevalent, especially in patients with cardiovascular and neurological disorders. It has important detrimental effects on sleep quality and oxygenation, resulting in daytime sleepiness and fatigue, impaired quality of life, and in some instances, increased risk of morbidity and mortality. Treatments are limited currently to oxygen and positive airway pressure breathing, which suffer from compliance issues and lack of randomized long-term data. In certain patient populations (e.g., heart failure with reduced ejection fraction patients), certain forms of positive airway pressure breathing are contraindicated due to observed increases in all-cause and cardiovascular mortality. This observation may be due to the nonphysiological mechanism of positive airway pressure breathing and its deleterious hemodynamic effects in patients with reduced ejection fractions. Thus, additional approaches to treating CSA are critically needed. One possible alternative approach is phrenic nerve stimulation. Phrenic nerve stimulation represents a more physiological means for restoring nocturnal breathing. Surgically implanted phrenic nerve stimulation systems have been around for many years, but due to their highly invasive nature, they have only been used for extreme situations such as ventilator-dependent tetraplegia. Over the past decade, a transvenous phrenic nerve stimulation system has been developed and evaluated for the treatment of CSA. A series of studies have demonstrated the feasibility, safety, and efficacy of transvenous phrenic nerve stimulation for the treatment of CSA." @default.
• W2793272954 created "2018-03-29" @default.
• W2793272954 creator A5066384461 @default.
• W2793272954 date "2018-01-01" @default.
• W2793272954 modified "2023-09-26" @default.
• W2793272954 title "Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea" @default.
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• W2793272954 doi "https://doi.org/10.1016/b978-0-12-805353-9.00110-8" @default.
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