Matches in SemOpenAlex for { <https://semopenalex.org/work/W279328445> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W279328445 abstract "Recent studies on the pathogenesis of myocardial ischemia have elucidated the role of coronary vasospasm in angina at rest [1,2]. Also recently it was shown that organic nitrate compounds like isosorbide dinitrate (ISDN), given i.V., have a marked efficacy in preventing episodes of vasospasm in unstable angina [3], confirming the critical usefulness of these drugs as already well established, indeed, for more than a century [4]. In vasospastic angina, i.v. treatment with nitrates was preferred to oral treatment to avoid the enzymatic degradation which nitrates undergo after first pass through the liver after instestinal absorption. In fact, pharmacokinetic studies of oral ISDN have shown that it is mainly transformed by the liver into two active metabolites: isosorbide-5-mononitrate (IS-5-MN) and -2-mononitrate (IS-2-MN) [5]. Of these two, taking into account both the pharmacokinetic properties and the vascular effects, the 5-mononitrate appears to be the most effective [5,6], when administered orally." @default.
- W279328445 created "2016-06-24" @default.
- W279328445 creator A5014672753 @default.
- W279328445 creator A5018118217 @default.
- W279328445 creator A5043593248 @default.
- W279328445 creator A5046191150 @default.
- W279328445 creator A5054910944 @default.
- W279328445 creator A5056652648 @default.
- W279328445 creator A5072095173 @default.
- W279328445 date "1985-01-01" @default.
- W279328445 modified "2023-10-14" @default.
- W279328445 title "Efficacy of Isosorbide-5-Mononitrate in the Prevention of Induced Attacks of Vasospastic Angina: Preliminary Results" @default.
- W279328445 cites W1526871402 @default.
- W279328445 cites W1543593316 @default.
- W279328445 cites W1967422186 @default.
- W279328445 cites W1975092445 @default.
- W279328445 cites W1978644822 @default.
- W279328445 cites W1979871046 @default.
- W279328445 cites W1980146561 @default.
- W279328445 cites W2014223813 @default.
- W279328445 cites W2015237162 @default.
- W279328445 cites W2025681425 @default.
- W279328445 cites W2032775574 @default.
- W279328445 cites W2032798442 @default.
- W279328445 cites W2053503744 @default.
- W279328445 cites W2069939957 @default.
- W279328445 cites W2072992417 @default.
- W279328445 cites W86724165 @default.
- W279328445 doi "https://doi.org/10.1007/978-3-642-70234-1_28" @default.
- W279328445 hasPublicationYear "1985" @default.
- W279328445 type Work @default.
- W279328445 sameAs 279328445 @default.
- W279328445 citedByCount "1" @default.
- W279328445 crossrefType "book-chapter" @default.
- W279328445 hasAuthorship W279328445A5014672753 @default.
- W279328445 hasAuthorship W279328445A5018118217 @default.
- W279328445 hasAuthorship W279328445A5043593248 @default.
- W279328445 hasAuthorship W279328445A5046191150 @default.
- W279328445 hasAuthorship W279328445A5054910944 @default.
- W279328445 hasAuthorship W279328445A5056652648 @default.
- W279328445 hasAuthorship W279328445A5072095173 @default.
- W279328445 hasConcept C112705442 @default.
- W279328445 hasConcept C126322002 @default.
- W279328445 hasConcept C164705383 @default.
- W279328445 hasConcept C178790620 @default.
- W279328445 hasConcept C185592680 @default.
- W279328445 hasConcept C2776161765 @default.
- W279328445 hasConcept C2776915459 @default.
- W279328445 hasConcept C2777736543 @default.
- W279328445 hasConcept C2778425758 @default.
- W279328445 hasConcept C2778492647 @default.
- W279328445 hasConcept C2778506911 @default.
- W279328445 hasConcept C2778949068 @default.
- W279328445 hasConcept C42219234 @default.
- W279328445 hasConcept C500558357 @default.
- W279328445 hasConcept C71924100 @default.
- W279328445 hasConcept C98274493 @default.
- W279328445 hasConceptScore W279328445C112705442 @default.
- W279328445 hasConceptScore W279328445C126322002 @default.
- W279328445 hasConceptScore W279328445C164705383 @default.
- W279328445 hasConceptScore W279328445C178790620 @default.
- W279328445 hasConceptScore W279328445C185592680 @default.
- W279328445 hasConceptScore W279328445C2776161765 @default.
- W279328445 hasConceptScore W279328445C2776915459 @default.
- W279328445 hasConceptScore W279328445C2777736543 @default.
- W279328445 hasConceptScore W279328445C2778425758 @default.
- W279328445 hasConceptScore W279328445C2778492647 @default.
- W279328445 hasConceptScore W279328445C2778506911 @default.
- W279328445 hasConceptScore W279328445C2778949068 @default.
- W279328445 hasConceptScore W279328445C42219234 @default.
- W279328445 hasConceptScore W279328445C500558357 @default.
- W279328445 hasConceptScore W279328445C71924100 @default.
- W279328445 hasConceptScore W279328445C98274493 @default.
- W279328445 hasLocation W2793284451 @default.
- W279328445 hasOpenAccess W279328445 @default.
- W279328445 hasPrimaryLocation W2793284451 @default.
- W279328445 hasRelatedWork W12772115 @default.
- W279328445 hasRelatedWork W1596740008 @default.
- W279328445 hasRelatedWork W1683065694 @default.
- W279328445 hasRelatedWork W1963513344 @default.
- W279328445 hasRelatedWork W1964320462 @default.
- W279328445 hasRelatedWork W2008993087 @default.
- W279328445 hasRelatedWork W2046429318 @default.
- W279328445 hasRelatedWork W2047550114 @default.
- W279328445 hasRelatedWork W2074856202 @default.
- W279328445 hasRelatedWork W2143286554 @default.
- W279328445 hasRelatedWork W225248377 @default.
- W279328445 hasRelatedWork W2394253583 @default.
- W279328445 hasRelatedWork W2396412635 @default.
- W279328445 hasRelatedWork W2403002408 @default.
- W279328445 hasRelatedWork W2409134322 @default.
- W279328445 hasRelatedWork W2413748861 @default.
- W279328445 hasRelatedWork W2439901108 @default.
- W279328445 hasRelatedWork W298943228 @default.
- W279328445 hasRelatedWork W46681661 @default.
- W279328445 hasRelatedWork W93464650 @default.
- W279328445 isParatext "false" @default.
- W279328445 isRetracted "false" @default.
- W279328445 magId "279328445" @default.
- W279328445 workType "book-chapter" @default.