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• W2793286987 endingPage "172" @default.
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• W2793286987 abstract "Hepatitis C virus plays a significant role in the development of hepatocellular carcinoma (HCC) globally. The pathogenic mechanisms of hepatocellular carcinoma with HCV infection are generally linked with inflammation, cytokines, fibrosis, cellular signaling pathways, and liver cell proliferation modulating pathways. HCV encoded proteins (Core, NS3, NS4, NS5A) interact with a broad range of hepatocytes derived factors to modulate an array of activities such as cell signaling, DNA repair, transcription and translational regulation, cell propagation, apoptosis, membrane topology. These four viral proteins are also implicated to show a strong conversion potential in tissue culture. Furthermore, Core and NS5A also trigger the accretion of the β-catenin pathway as a common target to contribute viral induced transformation. There is a strong association between HCV variants within Core, NS4, and NS5A and host single nucleotide polymorphisms (SNPs) with the HCC pathogenesis. Identification of such viral mutants and host SNPs is very critical to determine the risk of HCC and response to antiviral therapy. In this review, we highlight the association of key variants, mutated proteins, and host SNPs in development of HCV induced HCC. How such viral mutants may modulate the interaction with cellular host machinery is also discussed." @default.
• W2793286987 created "2018-03-29" @default.
• W2793286987 creator A5037262248 @default.
• W2793286987 creator A5054236996 @default.
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• W2793286987 creator A5075708814 @default.
• W2793286987 creator A5079947086 @default.
• W2793286987 creator A5083891989 @default.
• W2793286987 date "2018-06-01" @default.
• W2793286987 modified "2023-09-25" @default.
• W2793286987 title "Association of HCV mutated proteins and host SNPs in the development of hepatocellular carcinoma" @default.
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