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• W2793288889 abstract "We have identified the transmembrane collagen, COL-99, in a genetic screen for novel genes involved in axon guidance in the nematode C. elegans. COL-99 is similar to transmembrane collagens type XIII, XXIII and XXV in vertebrates. col-99 mutants exhibit guidance defects in axons extending along the major longitudinal axon tracts, most prominently the left ventral nerve cord (VNC). COL-99 is expressed in the hypodermis during the time of axon outgrowth. We provide evidence that a furin cleavage site in COL-99 is essential for function, suggesting that COL-99 is released from the cells producing it. Vertebrate homologs of COL-99 have been shown to be expressed in mammalian nervous systems and linked to various neurological disease but have not been associated with guidance of extending neurons. col-99 acts genetically with the discoidin domain receptors ddr-1 and ddr-2, which are expressed by neurons affected in col-99 mutants. Discoidin domain receptors are activated by collagens in vertebrates. DDR-1 and DDR-2 may function as receptors for COL-99. Our results establish a novel role for a transmembrane collagen in axonal guidance and asymmetry establishment of the VNC." @default.
• W2793288889 created "2018-03-29" @default.
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• W2793288889 date "2018-06-01" @default.
• W2793288889 modified "2023-09-27" @default.
• W2793288889 title "The transmembrane collagen COL-99 guides longitudinally extending axons in C. elegans" @default.
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• W2793288889 doi "https://doi.org/10.1016/j.mcn.2018.03.003" @default.
• W2793288889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29550247" @default.
• W2793288889 hasPublicationYear "2018" @default.
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