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- W2793290015 endingPage "144" @default.
- W2793290015 startingPage "135" @default.
- W2793290015 abstract "Class III adenylate cyclases (ACs) are widespread signaling proteins, which translate diverse intracellular and extracellular stimuli into a uniform intracellular signal. They are typically composed of an N-terminal array of input domains and transducers, followed C-terminally by a catalytic domain, which, as a dimer, generates the second messenger cAMP. The input domains, which receive stimuli, and the transducers, which propagate the signals, are often found in other signaling proteins. The nature of stimuli and the regulatory mechanisms of ACs have been studied experimentally in only a few cases, and even in these, important questions remain open, such as whether eukaryotic ACs regulated by G protein-coupled receptors can also receive stimuli through their own membrane domains. Here we survey the current knowledge on regulation and intramolecular signal propagation in ACs and draw comparisons to other signaling proteins. We highlight the pivotal role of a recently identified cyclase-specific transducer element located N-terminally of many AC catalytic domains, suggesting an intramolecular signaling capacity." @default.
- W2793290015 created "2018-03-29" @default.
- W2793290015 creator A5004439886 @default.
- W2793290015 creator A5030962194 @default.
- W2793290015 creator A5033224684 @default.
- W2793290015 date "2018-06-01" @default.
- W2793290015 modified "2023-09-24" @default.
- W2793290015 title "Adenylate cyclases: Receivers, transducers, and generators of signals" @default.
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