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- W2793298778 abstract "The atomic force microscope (AFM) has found broad use in the biological sciences largely due to its ability to acquire three-dimensional, high resolution images of native structures (molecules, cells, tissues) under fluid in near-physiological conditions. Since AFM is relatively non-destructive and requires minimal sample preparation (i.e. no coating/fixing/labeling), it is frequently used to monitor dynamic events. One of the challenges of traditional AFMs has been temporal resolution – acquiring scans at high enough speeds to capture biological processes in real-time. With traditional AFMs we can easily observe the “before” and “after” structures but very rarely can we capture the kinetics. Now we can observe the progression of these reactions and visualize their intermediate forms. With the arrival of video rate AFMs, we have a new set of standards enabling high resolution imaging of dynamic events at high speeds, up to 625 lines/second (10 frames per second). This is about 300x faster than typical AFMs and 10x faster than current “fast scanning” AFMs. Video rate AFMs are ideal for researching dynamic events and have enabled a new set of experiments including biochemical reactions, membrane studies, conformational changes, self-assembly and degradation. In most cases the spatial resolution is not compromised enabling us to locate the target or active site while tracking the progression of the reaction. We will present a set of data to illustrate the potential of this new capability. Examples include DNA digestion and cleavage, molecular structure and rearrangement in the bacteriorhodopsin membrane, assembly of Type I collagen into fibrils and dynamic motion of CTAB hemi-micelles at the solid (HOPG) – liquid (aqueous buffer) interface." @default.
- W2793298778 created "2018-03-29" @default.
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- W2793298778 date "2018-02-01" @default.
- W2793298778 modified "2023-10-17" @default.
- W2793298778 title "Video Rate Atomic Force Microscopy of Biological Samples" @default.
- W2793298778 doi "https://doi.org/10.1016/j.bpj.2017.11.2127" @default.
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