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• W2793307219 abstract "THE MORBIDITY AND MORTALITY associated with cardiac surgery using cardiopulmonary bypass (CPB) remains high despite advances in surgical technique and anesthetic management. 1 McGuinness S.P. Parke R.L. Drummond K. et al. A multicenter, randomized, controlled phase IIb trial of avoidance of hyperoxemia during cardiopulmonary bypass. Anesthesiology. 2016; 125: 465-473 Crossref PubMed Scopus (38) Google Scholar Much of this morbidity can be attributed to tissue malperfusion and hypoxia in the perioperative period. Indeed, CPB-related microcirculatory heterogeneity, cardiac dysfunction, hypothermia, fluid shifts, and allogeneic blood transfusion all contribute to impaired tissue oxygenation. 2 Spoelstra-de Man A.M. Smit B. Oudemans-van Straaten H.M. et al. Cardiovascular effects of hyperoxia during and after cardiac surgery. Anaesthesia. 2015; 70: 1307-1319 Crossref PubMed Scopus (42) Google Scholar Traditionally, high partial pressures of oxygen (PaO2) have been used to maximize tissue oxygen delivery during cardiac surgery. Dissolved oxygen may be of particular benefit in this setting, where patients often are hemodiluted and a hyperoxic PaO2 can increase delivery of this dissolved component. The increased PaO2 is also thought to impart an increased oxygen reserve, providing a buffer in the event of significant interruption of ventilation or profound hemodynamic instability. In addition to improving oxygen delivery to vulnerable tissues, there are numerous other beneficial effects of hyperoxia during cardiac surgery. These include improved patient safety, salutary hemodynamic effects, reduction in overall gas microemboli, and a potential role for cerebral preconditioning and protection. 3 Young R.W. Hyperoxia: A review of the risks and benefits in adult cardiac surgery. J Extra Corpor Technol. 2012; 44: 241-249 PubMed Google Scholar , 4 Murkin J.M. Adams S.J. Novick R.J. et al. Monitoring brain oxygen saturation during coronary bypass surgery: A randomized, prospective study. Anesth Analg. 2007; : 104 Google Scholar" @default.
• W2793307219 created "2018-03-29" @default.
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• W2793307219 date "2019-07-01" @default.
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• W2793307219 title "Pro: Hyperoxia Should Be Used During Cardiac Surgery" @default.
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• W2793307219 doi "https://doi.org/10.1053/j.jvca.2018.02.015" @default.
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