FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793341569> ?p ?o ?g. }

• W2793341569 abstract "As antique as Dioscorides era are the first records on using Chelidonium as a remedy to several sicknesses. Inspired by the signatura rerum principle and an apparent ancient folk tradition, various indications were given, such as anti-jaundice and cholagogue, pain-relieving, and quite often mentioned-ophthalmological problems. Central and Eastern European folk medicine has always been using this herb extensively. In this region, the plant is known under many unique vernacular names, especially in Slavonic languages, associated or not with old Greek relation to chelidon-the swallow. Typically for Papaveroidae subfamily, yellow-colored latex is produced in abundance and leaks intensely upon injury. Major pharmacologically relevant components, most of which were first isolated over a century ago, are isoquinoline alkaloids-berberine, chelerythrine, chelidonine, coptisine, sanguinarine. Modern pharmacology took interest in this herb but it has not ended up in gaining an officially approved and evidence-based herbal medicine status. On the contrary, the number of relevant studies and publications tended to drop. Recently, some controversial reports and sometimes insufficiently proven studies appeared, suggesting anticancer properties. Anticancer potential was in line with anecdotical knowledge spread in East European countries, however, in the absence of directly-acting cytostatic compounds, some other mechanisms might be involved. Other properties that could boost the interest in this herb are antimicrobial and antiviral activities. Being a common synanthropic weed or ruderal plant, C. majus spreads in all temperate Eurasia and acclimates well to North America. Little is known about the natural variation of bioactive metabolites, including several aforementioned isoquinoline alkaloids. In this review, we put together older and recent literature data on phytochemistry, pharmacology, and clinical studies on C. majus aiming at a critical evaluation of state-of-the-art from the viewpoint of historical and folk indications. The controversies around this herb, the safety and drug quality issues and a prospective role in phytotherapy are discussed as well." @default.
• W2793341569 created "2018-03-29" @default.
• W2793341569 creator A5008651222 @default.
• W2793341569 creator A5029125001 @default.
• W2793341569 creator A5049501522 @default.
• W2793341569 creator A5070652282 @default.
• W2793341569 creator A5073048770 @default.
• W2793341569 creator A5073866756 @default.
• W2793341569 date "2018-04-11" @default.
• W2793341569 modified "2023-10-17" @default.
• W2793341569 title "Greater Celandine's Ups and Downs−21 Centuries of Medicinal Uses of Chelidonium majus From the Viewpoint of Today's Pharmacology" @default.
• W2793341569 cites W1496886519 @default.
• W2793341569 cites W1516872401 @default.
• W2793341569 cites W1545076822 @default.
• W2793341569 cites W1768470176 @default.
• W2793341569 cites W1801422357 @default.
• W2793341569 cites W1959324886 @default.
• W2793341569 cites W1969651718 @default.
• W2793341569 cites W1970082049 @default.
• W2793341569 cites W1971819079 @default.
• W2793341569 cites W1973263584 @default.
• W2793341569 cites W1974770862 @default.
• W2793341569 cites W1978061151 @default.
• W2793341569 cites W1978850711 @default.
• W2793341569 cites W1978990715 @default.
• W2793341569 cites W1981820415 @default.
• W2793341569 cites W1983524652 @default.
• W2793341569 cites W1983937457 @default.
• W2793341569 cites W1985116973 @default.
• W2793341569 cites W1985406406 @default.
• W2793341569 cites W1986668716 @default.
• W2793341569 cites W1987288693 @default.
• W2793341569 cites W1987841130 @default.
• W2793341569 cites W1988327685 @default.
• W2793341569 cites W1989282144 @default.
• W2793341569 cites W1990878047 @default.
• W2793341569 cites W1990955547 @default.
• W2793341569 cites W1993206995 @default.
• W2793341569 cites W1993308285 @default.
• W2793341569 cites W1997133926 @default.
• W2793341569 cites W1998607332 @default.
• W2793341569 cites W2001399140 @default.
• W2793341569 cites W2005430406 @default.
• W2793341569 cites W2006089975 @default.
• W2793341569 cites W2007432278 @default.
• W2793341569 cites W2011405860 @default.
• W2793341569 cites W2013600365 @default.
• W2793341569 cites W2014128217 @default.
• W2793341569 cites W2014519057 @default.
• W2793341569 cites W2014701895 @default.
• W2793341569 cites W2014814150 @default.
• W2793341569 cites W2017862011 @default.
• W2793341569 cites W2020975790 @default.
• W2793341569 cites W2022394892 @default.
• W2793341569 cites W2025685083 @default.
• W2793341569 cites W2026483033 @default.
• W2793341569 cites W2026935265 @default.
• W2793341569 cites W2029070943 @default.
• W2793341569 cites W2029157760 @default.
• W2793341569 cites W2030109758 @default.
• W2793341569 cites W2030717441 @default.
• W2793341569 cites W2033711500 @default.
• W2793341569 cites W2033973950 @default.
• W2793341569 cites W2034386589 @default.
• W2793341569 cites W2036372490 @default.
• W2793341569 cites W2036808990 @default.
• W2793341569 cites W2038501020 @default.
• W2793341569 cites W2041940646 @default.
• W2793341569 cites W2047147957 @default.
• W2793341569 cites W2048247853 @default.
• W2793341569 cites W2050793292 @default.
• W2793341569 cites W2051320969 @default.
• W2793341569 cites W2052892187 @default.
• W2793341569 cites W2054523973 @default.
• W2793341569 cites W2055433647 @default.
• W2793341569 cites W2056622720 @default.
• W2793341569 cites W2056892226 @default.
• W2793341569 cites W2057165002 @default.
• W2793341569 cites W2057388647 @default.
• W2793341569 cites W2059149108 @default.
• W2793341569 cites W2059621998 @default.
• W2793341569 cites W2061940444 @default.
• W2793341569 cites W2062711214 @default.
• W2793341569 cites W2063021295 @default.
• W2793341569 cites W2064581369 @default.
• W2793341569 cites W2068870102 @default.
• W2793341569 cites W2069175331 @default.
• W2793341569 cites W2070475754 @default.
• W2793341569 cites W2070611226 @default.
• W2793341569 cites W2070771507 @default.
• W2793341569 cites W2073040798 @default.
• W2793341569 cites W2079593468 @default.
• W2793341569 cites W2080477694 @default.
• W2793341569 cites W2080493407 @default.
• W2793341569 cites W2080695087 @default.
• W2793341569 cites W2081257645 @default.
• W2793341569 cites W2081862545 @default.
• W2793341569 cites W2083812479 @default.
• W2793341569 cites W2086200562 @default.
• W2793341569 cites W2086654944 @default.

• next