FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793348430> ?p ?o ?g. }

• W2793348430 endingPage "1637" @default.
• W2793348430 startingPage "1627" @default.
• W2793348430 abstract "The age-related loss of muscle mass is related to the loss of innervating motor neurons and denervation of muscle fibres. Not all denervated muscle fibres are degraded; some may be reinnervated by an adjacent surviving neuron, which expands the innervating motor unit proportional to the numbers of fibres rescued. Enlarged motor units have larger motor unit potentials when measured using electrophysiological techniques. We recorded much larger motor unit potentials in relatively healthy older men compared to young men, but the older men with the smallest muscles (sarcopenia) had smaller motor unit potentials than healthy older men. These findings suggest that healthy older men reinnervate large numbers of muscle fibres to compensate for declining motor neuron numbers, but a failure to do so contributes to muscle loss in sarcopenic men.Sarcopenia results from the progressive loss of skeletal muscle mass and reduced function in older age. It is likely to be associated with the well-documented reduction of motor unit numbers innervating limb muscles and the increase in size of surviving motor units via reinnervation of denervated fibres. However, no evidence exists to confirm the extent of motor unit remodelling in sarcopenic individuals. The aim of the present study was to compare motor unit size and number between young (n = 48), non-sarcopenic old (n = 13), pre-sarcopenic (n = 53) and sarcopenic (n = 29) men. Motor unit potentials (MUPs) were isolated from intramuscular and surface EMG recordings. The motor unit numbers were reduced in all groups of old compared with young men (all P < 0.001). MUPs were higher in non-sarcopenic and pre-sarcopenic men compared with young men (P = 0.039 and 0.001 respectively), but not in the vastus lateralis of sarcopenic old (P = 0.485). The results suggest that extensive motor unit remodelling occurs relatively early during ageing, exceeds the loss of muscle mass and precedes sarcopenia. Reinnervation of denervated muscle fibres probably expands the motor unit size in the non-sarcopenic and pre-sarcopenic old, but not in the sarcopenic old. These findings suggest that a failure to expand the motor unit size distinguishes sarcopenic from pre-sarcopenic muscles." @default.
• W2793348430 created "2018-03-29" @default.
• W2793348430 creator A5008341202 @default.
• W2793348430 creator A5020407714 @default.
• W2793348430 creator A5043861812 @default.
• W2793348430 creator A5044466332 @default.
• W2793348430 creator A5052754584 @default.
• W2793348430 creator A5053664052 @default.
• W2793348430 creator A5053848570 @default.
• W2793348430 creator A5055904059 @default.
• W2793348430 date "2018-03-23" @default.
• W2793348430 modified "2023-10-12" @default.
• W2793348430 title "Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men" @default.
• W2793348430 cites W1497541115 @default.
• W2793348430 cites W1525082934 @default.
• W2793348430 cites W1870980090 @default.
• W2793348430 cites W1895834348 @default.
• W2793348430 cites W1941728630 @default.
• W2793348430 cites W1967263478 @default.
• W2793348430 cites W1982957249 @default.
• W2793348430 cites W1988786949 @default.
• W2793348430 cites W1998648979 @default.
• W2793348430 cites W2000308123 @default.
• W2793348430 cites W2005730609 @default.
• W2793348430 cites W2006321209 @default.
• W2793348430 cites W2015194385 @default.
• W2793348430 cites W2021469683 @default.
• W2793348430 cites W2025974650 @default.
• W2793348430 cites W2033533841 @default.
• W2793348430 cites W2046117873 @default.
• W2793348430 cites W2050310744 @default.
• W2793348430 cites W2052258664 @default.
• W2793348430 cites W2055793546 @default.
• W2793348430 cites W2057023074 @default.
• W2793348430 cites W2072399660 @default.
• W2793348430 cites W2077390310 @default.
• W2793348430 cites W2081079988 @default.
• W2793348430 cites W2082630082 @default.
• W2793348430 cites W2087431155 @default.
• W2793348430 cites W2089206417 @default.
• W2793348430 cites W2101878820 @default.
• W2793348430 cites W2102902846 @default.
• W2793348430 cites W2110957605 @default.
• W2793348430 cites W2112151983 @default.
• W2793348430 cites W2116382217 @default.
• W2793348430 cites W2130375741 @default.
• W2793348430 cites W2152454882 @default.
• W2793348430 cites W2154107418 @default.
• W2793348430 cites W2164863345 @default.
• W2793348430 cites W2220447049 @default.
• W2793348430 cites W2304118364 @default.
• W2793348430 cites W2333271618 @default.
• W2793348430 cites W2396446279 @default.
• W2793348430 cites W2478127453 @default.
• W2793348430 cites W2512477469 @default.
• W2793348430 cites W2524600943 @default.
• W2793348430 cites W2537061192 @default.
• W2793348430 cites W2566070385 @default.
• W2793348430 cites W2604437538 @default.
• W2793348430 cites W2611701272 @default.
• W2793348430 cites W2612195624 @default.
• W2793348430 cites W2747298618 @default.
• W2793348430 cites W2790276497 @default.
• W2793348430 doi "https://doi.org/10.1113/jp275520" @default.
• W2793348430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5924831" @default.
• W2793348430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29527694" @default.
• W2793348430 hasPublicationYear "2018" @default.
• W2793348430 type Work @default.
• W2793348430 sameAs 2793348430 @default.
• W2793348430 citedByCount "101" @default.
• W2793348430 countsByYear W27933484302018 @default.
• W2793348430 countsByYear W27933484302019 @default.
• W2793348430 countsByYear W27933484302020 @default.
• W2793348430 countsByYear W27933484302021 @default.
• W2793348430 countsByYear W27933484302022 @default.
• W2793348430 countsByYear W27933484302023 @default.
• W2793348430 crossrefType "journal-article" @default.
• W2793348430 hasAuthorship W2793348430A5008341202 @default.
• W2793348430 hasAuthorship W2793348430A5020407714 @default.
• W2793348430 hasAuthorship W2793348430A5043861812 @default.
• W2793348430 hasAuthorship W2793348430A5044466332 @default.
• W2793348430 hasAuthorship W2793348430A5052754584 @default.
• W2793348430 hasAuthorship W2793348430A5053664052 @default.
• W2793348430 hasAuthorship W2793348430A5053848570 @default.
• W2793348430 hasAuthorship W2793348430A5055904059 @default.
• W2793348430 hasBestOaLocation W27933484301 @default.
• W2793348430 hasConcept C105702510 @default.
• W2793348430 hasConcept C126322002 @default.
• W2793348430 hasConcept C173172909 @default.
• W2793348430 hasConcept C2776214593 @default.
• W2793348430 hasConcept C2776752467 @default.
• W2793348430 hasConcept C2776805190 @default.
• W2793348430 hasConcept C2777328239 @default.
• W2793348430 hasConcept C2777373429 @default.
• W2793348430 hasConcept C2777515770 @default.
• W2793348430 hasConcept C2779134260 @default.
• W2793348430 hasConcept C2779649809 @default.
• W2793348430 hasConcept C2781425072 @default.

• next