FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793350897> ?p ?o ?g. }

• W2793350897 endingPage "29" @default.
• W2793350897 startingPage "18" @default.
• W2793350897 abstract "Cumulative evidence suggests that cocaine use could alter the structure and function of different brain systems. However, the extent to which the altered brain structure and function possibly recover over time after cocaine abstinence remains less clear. The present study examines 39 male military veterans with different stages of cocaine addiction and long-term abstinence (from 1 year up to 30 years) and evaluates plausible changes in brain structure and function of specific brain regions that sub-serve addictions. These include the striatum that is involved in cocaine reward; the lateral prefrontal cortex (especially the dorsolateral PFC) that plays a major role in inhibitory control; the insula, which has been implicated in craving; and the medial orbitofrontal (OFC) and ventromedial prefrontal cortex (VMPFC) shown to play key roles in foresight and decision-making. The results suggest that there are differences in both brain structure (gray matter volume, GMV) and function between cocaine USERS and CONTROLS, with USERS showing plausible relative strengthening in neural systems for processing reward and craving, and relative weakening in neural systems involved in inhibitory control and decision-making. Examination of possible neural changes after abstinence suggests that presumed recovery occurs mostly in neural systems related to reward, craving, and inhibitory control, but to a lesser extent in neural systems related to decision-making. Given the limitations of the data in terms of a small sample size, as well as the lack of certainty about occasional use in the abstinent group, these results may be considered as preliminary. However, they are compelling in that they suggest that male military veterans cocaine USERS are indefinitely at a higher risk compared to CONTROLS for making lapses in judgment and decision-making leading to possible relapse, if reward salience and craving become more intense. Understanding the neurobiology of long-term cocaine abstinence in vulnerable populations and beyond could help devising better therapeutic strategies that prevent relapse." @default.
• W2793350897 created "2018-03-29" @default.
• W2793350897 creator A5002353808 @default.
• W2793350897 creator A5005027485 @default.
• W2793350897 creator A5020472362 @default.
• W2793350897 creator A5032494662 @default.
• W2793350897 creator A5032760966 @default.
• W2793350897 creator A5077565053 @default.
• W2793350897 creator A5079506325 @default.
• W2793350897 creator A5084759719 @default.
• W2793350897 date "2018-06-01" @default.
• W2793350897 modified "2023-10-08" @default.
• W2793350897 title "Presumed structural and functional neural recovery after long-term abstinence from cocaine in male military veterans" @default.
• W2793350897 cites W1482692645 @default.
• W2793350897 cites W1545863601 @default.
• W2793350897 cites W1561198779 @default.
• W2793350897 cites W1820118415 @default.
• W2793350897 cites W1841749037 @default.
• W2793350897 cites W1968328305 @default.
• W2793350897 cites W1968488284 @default.
• W2793350897 cites W1970414462 @default.
• W2793350897 cites W1983045607 @default.
• W2793350897 cites W1984123427 @default.
• W2793350897 cites W1986350274 @default.
• W2793350897 cites W1986835210 @default.
• W2793350897 cites W1991911963 @default.
• W2793350897 cites W1995793779 @default.
• W2793350897 cites W1999969384 @default.
• W2793350897 cites W2000753657 @default.
• W2793350897 cites W2000825098 @default.
• W2793350897 cites W2001565222 @default.
• W2793350897 cites W2002822547 @default.
• W2793350897 cites W2005904867 @default.
• W2793350897 cites W2007604257 @default.
• W2793350897 cites W2011048330 @default.
• W2793350897 cites W2011275122 @default.
• W2793350897 cites W2014401925 @default.
• W2793350897 cites W2016876321 @default.
• W2793350897 cites W2018017357 @default.
• W2793350897 cites W2021782736 @default.
• W2793350897 cites W2021986306 @default.
• W2793350897 cites W2021990305 @default.
• W2793350897 cites W2022235619 @default.
• W2793350897 cites W2027538885 @default.
• W2793350897 cites W2027739664 @default.
• W2793350897 cites W2030254718 @default.
• W2793350897 cites W2031716123 @default.
• W2793350897 cites W2036495407 @default.
• W2793350897 cites W2042448573 @default.
• W2793350897 cites W2044820918 @default.
• W2793350897 cites W2047713573 @default.
• W2793350897 cites W2053284348 @default.
• W2793350897 cites W2054747333 @default.
• W2793350897 cites W2058213757 @default.
• W2793350897 cites W2063713366 @default.
• W2793350897 cites W2064378998 @default.
• W2793350897 cites W2066982824 @default.
• W2793350897 cites W2072915828 @default.
• W2793350897 cites W2074705342 @default.
• W2793350897 cites W2077864003 @default.
• W2793350897 cites W2078530990 @default.
• W2793350897 cites W2079828968 @default.
• W2793350897 cites W2079872157 @default.
• W2793350897 cites W2081228315 @default.
• W2793350897 cites W2081652829 @default.
• W2793350897 cites W2105109101 @default.
• W2793350897 cites W2106315421 @default.
• W2793350897 cites W2106719141 @default.
• W2793350897 cites W2111986556 @default.
• W2793350897 cites W2116283675 @default.
• W2793350897 cites W2117808207 @default.
• W2793350897 cites W2123778240 @default.
• W2793350897 cites W2126293258 @default.
• W2793350897 cites W2126999739 @default.
• W2793350897 cites W2127679982 @default.
• W2793350897 cites W2129017955 @default.
• W2793350897 cites W2129688965 @default.
• W2793350897 cites W2130793920 @default.
• W2793350897 cites W2130978769 @default.
• W2793350897 cites W2131379141 @default.
• W2793350897 cites W2136550122 @default.
• W2793350897 cites W2136678677 @default.
• W2793350897 cites W2139213075 @default.
• W2793350897 cites W2141233050 @default.
• W2793350897 cites W2142013939 @default.
• W2793350897 cites W2149495603 @default.
• W2793350897 cites W2150258126 @default.
• W2793350897 cites W2152715596 @default.
• W2793350897 cites W2153797024 @default.
• W2793350897 cites W2157383890 @default.
• W2793350897 cites W2163989393 @default.
• W2793350897 cites W2164081174 @default.
• W2793350897 cites W2166464173 @default.
• W2793350897 cites W2169299157 @default.
• W2793350897 cites W2173844711 @default.
• W2793350897 cites W2602728118 @default.
• W2793350897 doi "https://doi.org/10.1016/j.pnpbp.2018.01.024" @default.
• W2793350897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5880688" @default.

• next