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• W2793363399 abstract "As a powerful antioxidant, vitamin C protects cells from oxidative damage by inhibiting production of free radicals. However, high levels of vitamin C shows cytotoxicity especially on cancerous cells through generating excessive ROS and blocking the energy homeostasis. Although the double-sided character of vitamin C has been extensively studied in many cell types, there is little research on the consequence of vitamin C treatment in stem cells. Here, we identified that high-dose vitamin C shows cellular toxicity on proliferating NSPCs. We also demonstrated that undifferentiated NSPCs are more sensitive to vitamin C-driven DNA damage than differentiated cells, due to higher expression of Glut genes. Finally, we showed that high-dose vitamin C selectively induces DNA damage on cancer stem cells rather than differentiated tumor cells, raising a possibility that vitamin C may be used to target cancer stem cells." @default.
• W2793363399 created "2018-03-29" @default.
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• W2793363399 date "2018-02-01" @default.
• W2793363399 modified "2023-10-13" @default.
• W2793363399 title "Cellular toxicity driven by high-dose vitamin C on normal and cancer stem cells" @default.
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• W2793363399 doi "https://doi.org/10.1016/j.bbrc.2018.02.083" @default.
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