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• W2793375430 endingPage "294" @default.
• W2793375430 startingPage "294" @default.
• W2793375430 abstract "This narrative systematic review evaluates growing evidence of an association between low maternal vitamin D status and increased risk of hypertensive disorders. The inclusion of interventional, observational, and dietary studies on vitamin D and all hypertensive disorders of pregnancy is a novel aspect of this review, providing a unique contribution to an intensively-researched area that still lacks a definitive conclusion. To date, trial evidence supports a protective effect of combined vitamin D and calcium supplementation against preeclampsia. Conflicting data for an association of vitamin D with gestational hypertensive disorders in observational studies arises from a number of sources, including large heterogeneity between study designs, lack of adherence to standardized perinatal outcome definitions, variable quality of analytical data for 25-hydroxyvitamin D (25(OH)D), and inconsistent data reporting of vitamin D status. While evidence does appear to lean towards an increased risk of gestational hypertensive disorders at 25(OH)D concentrations <50 nmol/L, caution should be exercised with dosing in trials, given the lack of data on long-term safety. The possibility that a fairly narrow target range for circulating 25(OH)D for achievement of clinically-relevant improvements requires further exploration. As hypertension alone, and not preeclampsia specifically, limits intrauterine growth, evaluation of the relationship between vitamin D status and all terms of hypertension in pregnancy is a clinically relevant area for research and should be prioritised in future randomised trials." @default.
• W2793375430 created "2018-03-29" @default.
• W2793375430 creator A5012893341 @default.
• W2793375430 creator A5080770366 @default.
• W2793375430 date "2018-03-01" @default.
• W2793375430 modified "2023-10-01" @default.
• W2793375430 title "Systematic Review of Vitamin D and Hypertensive Disorders of Pregnancy" @default.
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• W2793375430 doi "https://doi.org/10.3390/nu10030294" @default.
• W2793375430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5872712" @default.
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• W2793375430 hasPublicationYear "2018" @default.
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