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- W2793388652 abstract "Immunoglobulin heavy-chain (IgH) genes are assembled by DNA rearrangements that juxtapose a variable (VH), a diversity (DH), and a joining (JH) gene segment. Here, we report that in the absence of intergenic control region 1 (IGCR1), the intronic enhancer (Eμ) associates with the next available CTCF binding site located close to VH81X via putative heterotypic interactions involving YY1 and CTCF. The alternate Eμ/VH81X loop leads to formation of a distorted recombination center and altered DH rearrangements and disrupts chromosome conformation that favors distal VH recombination. Cumulatively, these features drive highly skewed, Eμ-dependent recombination of VH81X. Sequential deletion of CTCF binding regions on IGCR1-deleted alleles suggests that they influence recombination of single proximal VH gene segments. Our observations demonstrate that Eμ interacts differently with IGCR1- or VH-associated CTCF binding sites and thereby identify distinct roles for insulator-like elements in directing enhancer activity." @default.
- W2793388652 created "2018-03-29" @default.
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- W2793388652 date "2018-04-01" @default.
- W2793388652 modified "2023-10-14" @default.
- W2793388652 title "Sequential Enhancer Sequestration Dysregulates Recombination Center Formation at the IgH Locus" @default.
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- W2793388652 doi "https://doi.org/10.1016/j.molcel.2018.02.020" @default.
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