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- W2793396768 endingPage "870" @default.
- W2793396768 startingPage "860" @default.
- W2793396768 abstract "Acetylcholinesterase (AChE), a serine hydrolase, is primarily responsible for the termination of signal transmission in the cholinergic system, owing to its outstanding hydrolyzing potential. Its substrate acetylcholine (ACh), is a neurotransmitter of the cholinergic system, with a predominant effect on motor neurons involved in memory formation. So, by decreasing the activity of this enzyme by employment of specific inhibitors, a number of motor neuron disorders such as myasthenia gravis, glaucoma, Lewy body dementia, and Alzheimer’s disease, among others, can be treated. However, the current-available AChE inhibitors have several limitations in terms of efficacy, therapeutic range, and safety. Primarily due to the non-compliance of current therapies, new, effective and safe inhibitors are being searched for, especially those which act through multiple receptor sites, but do not elicit undesirable effects. In this regard, the evaluation of phytochemicals such as flavonoids, can be a rational approach. The therapeutic potential of flavonoids has already been recognized agaisnt several ailments. This review deals with various plant-derived flavonoids, their preclinical potential as AChE inhibitors, in established assays, possible mechanisms of action, and structural activity relationship (SAR). Subsequently, a number of plant-derived flavonoids with outstanding efficacy and potency as AChE inhibitors, the mechanistic, their safety profiles, and pharmacokinetic attributes have been discussed. Through derivatization of these reported flavonoids, some limitation in efficacy or pharmacokinetic parameters can be addressed. The selected flavonoids ought to be tested in clinical studies to discover new neuro-therapeutic candidates." @default.
- W2793396768 created "2018-03-29" @default.
- W2793396768 creator A5011962133 @default.
- W2793396768 creator A5019801076 @default.
- W2793396768 creator A5040140025 @default.
- W2793396768 creator A5084686394 @default.
- W2793396768 creator A5089425227 @default.
- W2793396768 date "2018-05-01" @default.
- W2793396768 modified "2023-10-16" @default.
- W2793396768 title "Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects" @default.
- W2793396768 cites W1469267021 @default.
- W2793396768 cites W1487878063 @default.
- W2793396768 cites W1835618335 @default.
- W2793396768 cites W1934746052 @default.
- W2793396768 cites W1964040391 @default.
- W2793396768 cites W1964141045 @default.
- W2793396768 cites W1967372871 @default.
- W2793396768 cites W1972197746 @default.
- W2793396768 cites W1973018875 @default.
- W2793396768 cites W1973305306 @default.
- W2793396768 cites W1976233139 @default.
- W2793396768 cites W1979078001 @default.
- W2793396768 cites W1981938906 @default.
- W2793396768 cites W1982728268 @default.
- W2793396768 cites W2000147022 @default.
- W2793396768 cites W2001876358 @default.
- W2793396768 cites W2005326953 @default.
- W2793396768 cites W2011831683 @default.
- W2793396768 cites W2017327362 @default.
- W2793396768 cites W2017343996 @default.
- W2793396768 cites W2018976898 @default.
- W2793396768 cites W2027085225 @default.
- W2793396768 cites W2030609239 @default.
- W2793396768 cites W2038284321 @default.
- W2793396768 cites W2039635052 @default.
- W2793396768 cites W2042716004 @default.
- W2793396768 cites W2044501281 @default.
- W2793396768 cites W2045972775 @default.
- W2793396768 cites W2061473725 @default.
- W2793396768 cites W2068327579 @default.
- W2793396768 cites W2068813102 @default.
- W2793396768 cites W2077360528 @default.
- W2793396768 cites W2085801143 @default.
- W2793396768 cites W2085907924 @default.
- W2793396768 cites W2088226047 @default.
- W2793396768 cites W2088572958 @default.
- W2793396768 cites W2088746555 @default.
- W2793396768 cites W2090007281 @default.
- W2793396768 cites W2097290405 @default.
- W2793396768 cites W2111315178 @default.
- W2793396768 cites W2122176511 @default.
- W2793396768 cites W2123965918 @default.
- W2793396768 cites W2131203932 @default.
- W2793396768 cites W2135038302 @default.
- W2793396768 cites W2143500009 @default.
- W2793396768 cites W2157461655 @default.
- W2793396768 cites W2166576096 @default.
- W2793396768 cites W2179824638 @default.
- W2793396768 cites W2195578925 @default.
- W2793396768 cites W2212108168 @default.
- W2793396768 cites W2215766721 @default.
- W2793396768 cites W2222436575 @default.
- W2793396768 cites W2226517899 @default.
- W2793396768 cites W2257356502 @default.
- W2793396768 cites W2279774211 @default.
- W2793396768 cites W2309851280 @default.
- W2793396768 cites W2323861480 @default.
- W2793396768 cites W2329844611 @default.
- W2793396768 cites W2333010261 @default.
- W2793396768 cites W2383203767 @default.
- W2793396768 cites W2464221582 @default.
- W2793396768 cites W2465893976 @default.
- W2793396768 cites W2469278957 @default.
- W2793396768 cites W2477706958 @default.
- W2793396768 cites W2481862540 @default.
- W2793396768 cites W2511021482 @default.
- W2793396768 cites W2516089837 @default.
- W2793396768 cites W2523262515 @default.
- W2793396768 cites W2536084338 @default.
- W2793396768 cites W2540856080 @default.
- W2793396768 cites W2542856291 @default.
- W2793396768 cites W2550559917 @default.
- W2793396768 cites W2552506015 @default.
- W2793396768 cites W2554115926 @default.
- W2793396768 cites W2554930114 @default.
- W2793396768 cites W2560019307 @default.
- W2793396768 cites W2577884818 @default.
- W2793396768 cites W2591309348 @default.
- W2793396768 cites W2595376144 @default.
- W2793396768 cites W2606244075 @default.
- W2793396768 cites W2607197136 @default.
- W2793396768 cites W2765562140 @default.
- W2793396768 cites W2766483623 @default.
- W2793396768 cites W2773193611 @default.
- W2793396768 cites W2784210808 @default.
- W2793396768 cites W2790652144 @default.
- W2793396768 cites W2963188327 @default.
- W2793396768 cites W52611150 @default.