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- W2793446145 abstract "Classically, brain cancers have been graded and diagnosed based on histology and risk stratified by clinical criteria. Recent advances in genomics and epigenomics have ushered in an era of defining cancers based on molecular criteria. These advances have increased our precision of identifying oncogenic driving events and, most importantly, increased our precision at predicting clinical outcome. For the first time in its history, the 2016 revision of the WHO Classification of Tumors of the Central Nervous System included molecular features as tumor classification criteria. Brain tumors can develop in the context of genetic cancer predisposition syndromes, such as Li-Fraumeni or Gorlin syndrome, but by far most commonly arise through the acquisition of somatic mutations and chromosome changes in the malignant cells. By taking a survey across this cancer landscape, certain themes emerge as being common events to drive cancer: DNA damage repair, genomic instability, mechanistic target of rapamycin pathway, sonic hedgehog pathway, hypoxia, and epigenetic dysfunction. Understanding these mechanisms is of paramount importance for improving targeted therapies, and for identifying the right patients for those therapies." @default.
- W2793446145 created "2018-03-29" @default.
- W2793446145 creator A5003718738 @default.
- W2793446145 creator A5009711079 @default.
- W2793446145 creator A5018379179 @default.
- W2793446145 date "2018-01-01" @default.
- W2793446145 modified "2023-09-27" @default.
- W2793446145 title "Brain cancer genomics and epigenomics" @default.
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- W2793446145 doi "https://doi.org/10.1016/b978-0-444-64076-5.00050-8" @default.
- W2793446145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29478614" @default.
- W2793446145 hasPublicationYear "2018" @default.
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