FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793499222> ?p ?o ?g. }

• W2793499222 endingPage "22" @default.
• W2793499222 startingPage "16" @default.
• W2793499222 abstract "Low-intensity pulsed ultrasound (LIPUS) has been used in both basic research and clinical settings for its therapeutic potential in promoting tissue healing. Clinical data has shown that LIPUS can accelerate fresh fracture healing. However, the treatment for aging osteoporosis and non-union is still unclear. In addition, the mechanism of ultrasound promoted bone healing has remained unknown.It is proposed that noninvasive ultrasound treatment can enhance local fluid flow within the tissue to initiate remodeling and regeneration. The goal of this study was to evaluate the effects of dynamic ultrasound in promoting cellular mechanotransduction within bioengineered organic scaffolds to trigger osteogenesis and mineralization.The experiment was designed in two-fold: to evaluate the role of LIPUS on osteoblastic-like (MC3T3) cell proliferation and mineralization in response to acoustic waves, using biomechanical rate-dependent signals in a bioreactor; and, to evaluate the new scaffold experimentation techniques, in order to generate a potential implantable biomaterial for orthopedic tissue regeneration and repair.LIPUS treatment on MC3T3 cells yielded enhanced cellular mineralization (**p < 0.001) in 3-D scaffolding, but reduced the total cell numbers (*p < 0.05), using Alizarin Red staining and cell counting analyses, respectively, in comparison to the control.This study suggests that LIPUS, if applied at proper frequency and duty cycle, can promote cell mineralization within the 3-D organic scaffold under in vitro setting. The translational component of this experiment seeks to draw a parallel to the potential pre-treatment of scaffolds for implantation before orthopedic surgery, which could prove to greatly benefit the patient in accelerating fracture healing and tissue regeneration.LIPUS stimulation was critical in contributing to the mechanical signaling transductions that activated bone enhancement parameters in MC3T3 cells regulated by bioreactor, and thus has potential to change how we pretreat scaffolds for orthopedic surgery and noninvasively accelerate healing in the future, e.g., in an extreme condition such as long-term space mission." @default.
• W2793499222 created "2018-03-29" @default.
• W2793499222 creator A5011583661 @default.
• W2793499222 creator A5019288050 @default.
• W2793499222 date "2018-07-01" @default.
• W2793499222 modified "2023-09-26" @default.
• W2793499222 title "MC3T3 infiltration and proliferation in bovine trabecular scaffold regulated by dynamic flow bioreactor and augmented by low-intensity pulsed ultrasound" @default.
• W2793499222 cites W133933228 @default.
• W2793499222 cites W148739240 @default.
• W2793499222 cites W1796744353 @default.
• W2793499222 cites W1812945538 @default.
• W2793499222 cites W1963886410 @default.
• W2793499222 cites W1967388572 @default.
• W2793499222 cites W1969196472 @default.
• W2793499222 cites W1974193257 @default.
• W2793499222 cites W1975198035 @default.
• W2793499222 cites W1990973180 @default.
• W2793499222 cites W1997844446 @default.
• W2793499222 cites W2000262289 @default.
• W2793499222 cites W2003035047 @default.
• W2793499222 cites W2014337155 @default.
• W2793499222 cites W2037866214 @default.
• W2793499222 cites W2044882340 @default.
• W2793499222 cites W2051774900 @default.
• W2793499222 cites W2058249306 @default.
• W2793499222 cites W2061100934 @default.
• W2793499222 cites W2065142165 @default.
• W2793499222 cites W2065324203 @default.
• W2793499222 cites W2071000192 @default.
• W2793499222 cites W2087578326 @default.
• W2793499222 cites W2107275638 @default.
• W2793499222 cites W2128057975 @default.
• W2793499222 cites W2139686794 @default.
• W2793499222 cites W2141219254 @default.
• W2793499222 cites W2142491318 @default.
• W2793499222 cites W2143228580 @default.
• W2793499222 cites W2143371479 @default.
• W2793499222 cites W2149943494 @default.
• W2793499222 cites W2174322495 @default.
• W2793499222 cites W2468894079 @default.
• W2793499222 cites W2604128148 @default.
• W2793499222 cites W2772716333 @default.
• W2793499222 doi "https://doi.org/10.1016/j.jot.2018.02.002" @default.
• W2793499222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6042526" @default.
• W2793499222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30035029" @default.
• W2793499222 hasPublicationYear "2018" @default.
• W2793499222 type Work @default.
• W2793499222 sameAs 2793499222 @default.
• W2793499222 citedByCount "3" @default.
• W2793499222 countsByYear W27934992222019 @default.
• W2793499222 countsByYear W27934992222022 @default.
• W2793499222 crossrefType "journal-article" @default.
• W2793499222 hasAuthorship W2793499222A5011583661 @default.
• W2793499222 hasAuthorship W2793499222A5019288050 @default.
• W2793499222 hasBestOaLocation W27934992221 @default.
• W2793499222 hasConcept C105702510 @default.
• W2793499222 hasConcept C126838900 @default.
• W2793499222 hasConcept C136229726 @default.
• W2793499222 hasConcept C143753070 @default.
• W2793499222 hasConcept C171056886 @default.
• W2793499222 hasConcept C185592680 @default.
• W2793499222 hasConcept C202751555 @default.
• W2793499222 hasConcept C2778260815 @default.
• W2793499222 hasConcept C2778550726 @default.
• W2793499222 hasConcept C2779727089 @default.
• W2793499222 hasConcept C49892992 @default.
• W2793499222 hasConcept C55493867 @default.
• W2793499222 hasConcept C71924100 @default.
• W2793499222 hasConcept C8337478 @default.
• W2793499222 hasConcept C86803240 @default.
• W2793499222 hasConcept C89429830 @default.
• W2793499222 hasConcept C95444343 @default.
• W2793499222 hasConceptScore W2793499222C105702510 @default.
• W2793499222 hasConceptScore W2793499222C126838900 @default.
• W2793499222 hasConceptScore W2793499222C136229726 @default.
• W2793499222 hasConceptScore W2793499222C143753070 @default.
• W2793499222 hasConceptScore W2793499222C171056886 @default.
• W2793499222 hasConceptScore W2793499222C185592680 @default.
• W2793499222 hasConceptScore W2793499222C202751555 @default.
• W2793499222 hasConceptScore W2793499222C2778260815 @default.
• W2793499222 hasConceptScore W2793499222C2778550726 @default.
• W2793499222 hasConceptScore W2793499222C2779727089 @default.
• W2793499222 hasConceptScore W2793499222C49892992 @default.
• W2793499222 hasConceptScore W2793499222C55493867 @default.
• W2793499222 hasConceptScore W2793499222C71924100 @default.
• W2793499222 hasConceptScore W2793499222C8337478 @default.
• W2793499222 hasConceptScore W2793499222C86803240 @default.
• W2793499222 hasConceptScore W2793499222C89429830 @default.
• W2793499222 hasConceptScore W2793499222C95444343 @default.
• W2793499222 hasFunder F4320306101 @default.
• W2793499222 hasFunder F4320310845 @default.
• W2793499222 hasLocation W27934992221 @default.
• W2793499222 hasLocation W27934992222 @default.
• W2793499222 hasLocation W27934992223 @default.
• W2793499222 hasLocation W27934992224 @default.
• W2793499222 hasOpenAccess W2793499222 @default.
• W2793499222 hasPrimaryLocation W27934992221 @default.
• W2793499222 hasRelatedWork W118248105 @default.

• next