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- W2793513620 abstract "Food allergy (FA) affects an estimated 8% of children in the United States and is associated with negative psychosocial effects on children with FA and their caregivers, as well as substantial economic burden. 1 Gupta R.S. Springston E.E. Warrier M.R. et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011; 128: e9-e17 Crossref PubMed Scopus (1021) Google Scholar , 2 Gupta R. Holdford D. Bilaver L. Dyer A. Holl J.L. Meltzer D. The economic impact of childhood food allergy in the United States. JAMA Pediatr. 2013; 167: 1026-1031 Crossref PubMed Scopus (288) Google Scholar , 3 Warren C.M. Otto A.K. Walkner M.M. Gupta R.S. Quality of life among food allergic patients and their caregivers. Curr Allergy Asthma Rep. 2016; 16: 38 Crossref PubMed Scopus (73) Google Scholar No approved treatment for FA exists, but several experimental therapies are presently under investigation, including oral immunotherapy (OIT), sublingual immunotherapy (SLIT), and epicutaneous immunotherapy (EPIT). [4] Nurmatov U. Dhami S. Arasi S. et al. Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy. 2017; 72: 1133-1147 Crossref PubMed Scopus (267) Google Scholar These therapies aim to desensitize patients through administration of gradually increasing doses of allergen, with goals ranging from protection against accidental ingestion to the development of sustained unresponsiveness with ad libitum allergen exposure. To facilitate the further development of these treatments, recruitment of participants for clinical trials is critical. Work in other fields has shown that the decision to enroll in clinical trials is influenced by many factors, including sociodemographics, cost, time, fear, and perceived benefits/risks of participation. [5] Walsh E. Sheridan A. Factors affecting patient participation in clinical trials in Ireland: a narrative review. Contemp Clin Trials Commun. 2016; 3: 23-31 Crossref PubMed Scopus (47) Google Scholar However, little remains known about which factors influence the decisions of families with FA to participate in clinical trials for emerging FA immunotherapies." @default.
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- W2793513620 date "2018-03-01" @default.
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- W2793513620 title "Parental and parent-perceived child interest in clinical trials for food allergen immunotherapy" @default.
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- W2793513620 doi "https://doi.org/10.1016/j.anai.2017.12.012" @default.
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