Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793542593> ?p ?o ?g. }
- W2793542593 endingPage "138" @default.
- W2793542593 startingPage "127" @default.
- W2793542593 abstract "Inflammatory cells such as macrophages can play a pro-tumorigenic role in the tumor stroma. Tumor-associated macrophages (TAMs) generally display an M2 phenotype with tumor-promoting activity; however, the mechanisms regulating the TAM phenotype remain unclear. Complement 5a (C5a) is a cytokine-like polypeptide that is generated during complement system activation and is known to promote tumor growth. Herein, we investigated the role of C5a on macrophage polarization in colon cancer metastasis in mice. We found that deficiency of the C5a receptor (C5aR) severely impairs the metastatic ability of implanted colon cancer cells. C5aR was expressed on TAMs, which exhibited an M2-like functional profile in colon cancer liver metastatic lesions. Furthermore, C5a mediated macrophage polarization and this process relied substantially on activation of the nuclear factor-kappa B (NF-κB) pathway. Finally, analysis of human colon carcinoma indicated that C5aR expression is negatively associated with tumor differentiation grade. Our results demonstrate that C5aR has a central role in regulating the M2 phenotype of TAMs, which in turn, contributes to hepatic metastasis of colon cancer through NF-κB signaling. C5a is a potential novel marker for cancer prognosis and drugs targeting complement system activation, specifically the C5aR pathway, may offer new therapeutic opportunities for colon cancer management." @default.
- W2793542593 created "2018-03-29" @default.
- W2793542593 creator A5004222912 @default.
- W2793542593 creator A5012904925 @default.
- W2793542593 creator A5013389489 @default.
- W2793542593 creator A5020471102 @default.
- W2793542593 creator A5021293751 @default.
- W2793542593 creator A5040366958 @default.
- W2793542593 creator A5041923573 @default.
- W2793542593 creator A5069689855 @default.
- W2793542593 creator A5070331807 @default.
- W2793542593 creator A5083423037 @default.
- W2793542593 creator A5091568946 @default.
- W2793542593 date "2018-05-01" @default.
- W2793542593 modified "2023-10-17" @default.
- W2793542593 title "Complement 5a stimulates macrophage polarization and contributes to tumor metastases of colon cancer" @default.
- W2793542593 cites W1480357432 @default.
- W2793542593 cites W1512564160 @default.
- W2793542593 cites W1828479613 @default.
- W2793542593 cites W1900099842 @default.
- W2793542593 cites W1970264868 @default.
- W2793542593 cites W1973037661 @default.
- W2793542593 cites W1973159760 @default.
- W2793542593 cites W1978286264 @default.
- W2793542593 cites W1979982103 @default.
- W2793542593 cites W1980485314 @default.
- W2793542593 cites W1980927217 @default.
- W2793542593 cites W1981852225 @default.
- W2793542593 cites W2008621673 @default.
- W2793542593 cites W2019011312 @default.
- W2793542593 cites W2020224761 @default.
- W2793542593 cites W2021955841 @default.
- W2793542593 cites W2023164440 @default.
- W2793542593 cites W2024312453 @default.
- W2793542593 cites W2025381786 @default.
- W2793542593 cites W2032550022 @default.
- W2793542593 cites W2037833540 @default.
- W2793542593 cites W2039183048 @default.
- W2793542593 cites W2040773741 @default.
- W2793542593 cites W2044419631 @default.
- W2793542593 cites W2055891785 @default.
- W2793542593 cites W2058250558 @default.
- W2793542593 cites W2058803247 @default.
- W2793542593 cites W2061123122 @default.
- W2793542593 cites W2066469619 @default.
- W2793542593 cites W2067432698 @default.
- W2793542593 cites W2067799433 @default.
- W2793542593 cites W2075524348 @default.
- W2793542593 cites W2076936113 @default.
- W2793542593 cites W2081399902 @default.
- W2793542593 cites W2085575652 @default.
- W2793542593 cites W2092844155 @default.
- W2793542593 cites W2100834680 @default.
- W2793542593 cites W2102540527 @default.
- W2793542593 cites W2102932869 @default.
- W2793542593 cites W2103577441 @default.
- W2793542593 cites W2105724560 @default.
- W2793542593 cites W2107567947 @default.
- W2793542593 cites W2109203270 @default.
- W2793542593 cites W2110325814 @default.
- W2793542593 cites W2117246760 @default.
- W2793542593 cites W2117735446 @default.
- W2793542593 cites W2121294918 @default.
- W2793542593 cites W2123414173 @default.
- W2793542593 cites W2126767360 @default.
- W2793542593 cites W2132485200 @default.
- W2793542593 cites W2133274452 @default.
- W2793542593 cites W2136964874 @default.
- W2793542593 cites W2141171505 @default.
- W2793542593 cites W2145431452 @default.
- W2793542593 cites W2147915982 @default.
- W2793542593 cites W2149142217 @default.
- W2793542593 cites W2149867445 @default.
- W2793542593 cites W2158642531 @default.
- W2793542593 cites W2163483059 @default.
- W2793542593 cites W2231512968 @default.
- W2793542593 cites W2273461839 @default.
- W2793542593 cites W2519607462 @default.
- W2793542593 cites W2548989939 @default.
- W2793542593 doi "https://doi.org/10.1016/j.yexcr.2018.03.009" @default.
- W2793542593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29551360" @default.
- W2793542593 hasPublicationYear "2018" @default.
- W2793542593 type Work @default.
- W2793542593 sameAs 2793542593 @default.
- W2793542593 citedByCount "57" @default.
- W2793542593 countsByYear W27935425932018 @default.
- W2793542593 countsByYear W27935425932019 @default.
- W2793542593 countsByYear W27935425932020 @default.
- W2793542593 countsByYear W27935425932021 @default.
- W2793542593 countsByYear W27935425932022 @default.
- W2793542593 countsByYear W27935425932023 @default.
- W2793542593 crossrefType "journal-article" @default.
- W2793542593 hasAuthorship W2793542593A5004222912 @default.
- W2793542593 hasAuthorship W2793542593A5012904925 @default.
- W2793542593 hasAuthorship W2793542593A5013389489 @default.
- W2793542593 hasAuthorship W2793542593A5020471102 @default.
- W2793542593 hasAuthorship W2793542593A5021293751 @default.
- W2793542593 hasAuthorship W2793542593A5040366958 @default.