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- W2793543910 endingPage "91" @default.
- W2793543910 startingPage "61" @default.
- W2793543910 abstract "An increase in pulsatile GnRH release is necessary and sufficient for the onset of puberty. However, the mechanism of the pubertal increase in GnRH release is elusive. In humans and non-human primates the GnRH neurosecretory system in the hypothalamus is already active at the infantile period exhibiting mature pulsatility of GnRH/LH release, but during the prepubertal period the GnRH neurosecretory system is suppressed by “central inhibition”, until brain functions governing behavioral and intellectual maturation occur. This article discusses the possible neural substrates and genes inhibiting the GnRH neurosecretory system during the prepubertal “brake” period and subsequent “reactivation” of the GnRH neurosecretory system initiating puberty. Although both kisspeptin and neurokinin B signaling undergo significant pubertal changes, they are unlikely candidates for the initiators of puberty, as at the infantile period they are also active, and similar to GnRH release during the prepubertal period their activity is low. Because environmental factors, such as nutrition and endocrine disruptors are known to modify the timing of puberty, epigenetic influence on GnRH neurons and regulatory networks is also discussed. The question of what triggers puberty remains until we have a clear answer to the mechanism of “central inhibition” during the prepubertal period and how it is reduced prior to the pubertal increase in GnRH release." @default.
- W2793543910 created "2018-03-29" @default.
- W2793543910 creator A5061445584 @default.
- W2793543910 date "2018-03-02" @default.
- W2793543910 modified "2023-09-23" @default.
- W2793543910 title "Postnatal Development of GnRH Neuronal Function" @default.
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- W2793543910 doi "https://doi.org/10.1002/9781119233275.ch4" @default.
- W2793543910 hasPublicationYear "2018" @default.
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