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- W2793556201 endingPage "e0192606" @default.
- W2793556201 startingPage "e0192606" @default.
- W2793556201 abstract "We investigated maternal obesity in inbred SM/J mice by assigning females to a high-fat diet or a low-fat diet at weaning, mating them to low-fat-fed males, cross-fostering the offspring to low-fat-fed SM/J nurses at birth, and weaning the offspring onto a high-fat or low-fat diet. A maternal high-fat diet exacerbated obesity in the high-fat-fed daughters, causing them to weigh more, have more fat, and have higher serum levels of leptin as adults, accompanied by dozens of gene expression changes and thousands of DNA methylation changes in their livers and hearts. Maternal diet particularly affected genes involved in RNA processing, immune response, and mitochondria. Between one-quarter and one-third of differentially expressed genes contained a differentially methylated region associated with maternal diet. An offspring high-fat diet reduced overall variation in DNA methylation, increased body weight and organ weights, increased long bone lengths and weights, decreased insulin sensitivity, and changed the expression of 3,908 genes in the liver. Although the offspring were more affected by their own diet, their maternal diet had epigenetic effects lasting through adulthood, and in the daughters these effects were accompanied by phenotypic changes relevant to obesity and diabetes." @default.
- W2793556201 created "2018-03-29" @default.
- W2793556201 creator A5020501294 @default.
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- W2793556201 date "2018-02-15" @default.
- W2793556201 modified "2023-09-25" @default.
- W2793556201 title "Maternal high-fat diet associated with altered gene expression, DNA methylation, and obesity risk in mouse offspring" @default.
- W2793556201 cites W1485381775 @default.
- W2793556201 cites W1533236567 @default.
- W2793556201 cites W1584360090 @default.
- W2793556201 cites W1679099184 @default.
- W2793556201 cites W1680376170 @default.
- W2793556201 cites W193903826 @default.
- W2793556201 cites W1958476984 @default.
- W2793556201 cites W1966327575 @default.
- W2793556201 cites W1967013632 @default.
- W2793556201 cites W1969470394 @default.
- W2793556201 cites W1975171570 @default.
- W2793556201 cites W1975301692 @default.
- W2793556201 cites W1975657147 @default.
- W2793556201 cites W1978848772 @default.
- W2793556201 cites W1979283297 @default.
- W2793556201 cites W1982389973 @default.
- W2793556201 cites W1983341496 @default.
- W2793556201 cites W1984806127 @default.
- W2793556201 cites W1985935160 @default.
- W2793556201 cites W1988507644 @default.
- W2793556201 cites W1993185333 @default.
- W2793556201 cites W1993378051 @default.
- W2793556201 cites W1994872818 @default.
- W2793556201 cites W1998558885 @default.
- W2793556201 cites W2003402014 @default.
- W2793556201 cites W2004873484 @default.
- W2793556201 cites W2009998546 @default.
- W2793556201 cites W2020509383 @default.
- W2793556201 cites W2022657181 @default.
- W2793556201 cites W2026468401 @default.
- W2793556201 cites W2026727437 @default.
- W2793556201 cites W2028232278 @default.
- W2793556201 cites W2030615146 @default.
- W2793556201 cites W2040243584 @default.
- W2793556201 cites W2040589287 @default.
- W2793556201 cites W2042586481 @default.
- W2793556201 cites W2049112623 @default.
- W2793556201 cites W2057948124 @default.
- W2793556201 cites W2060880575 @default.
- W2793556201 cites W2064176741 @default.
- W2793556201 cites W2067074932 @default.
- W2793556201 cites W2067521078 @default.
- W2793556201 cites W2068800010 @default.
- W2793556201 cites W2071246329 @default.
- W2793556201 cites W2071592190 @default.
- W2793556201 cites W2075074527 @default.
- W2793556201 cites W2077944070 @default.
- W2793556201 cites W2080035179 @default.
- W2793556201 cites W2083248611 @default.
- W2793556201 cites W2087642123 @default.
- W2793556201 cites W2091034183 @default.
- W2793556201 cites W2100072681 @default.
- W2793556201 cites W2100489386 @default.
- W2793556201 cites W2102108110 @default.
- W2793556201 cites W2103368550 @default.
- W2793556201 cites W2103724782 @default.
- W2793556201 cites W2103990329 @default.
- W2793556201 cites W2104651942 @default.
- W2793556201 cites W2114104545 @default.
- W2793556201 cites W2116192451 @default.
- W2793556201 cites W2117686645 @default.
- W2793556201 cites W2124040060 @default.
- W2793556201 cites W2124359985 @default.
- W2793556201 cites W2124429969 @default.
- W2793556201 cites W2124748744 @default.
- W2793556201 cites W2125558713 @default.
- W2793556201 cites W2128449418 @default.
- W2793556201 cites W2129550715 @default.
- W2793556201 cites W2130070821 @default.
- W2793556201 cites W2130947702 @default.
- W2793556201 cites W2131398405 @default.
- W2793556201 cites W2132572939 @default.
- W2793556201 cites W2135945926 @default.
- W2793556201 cites W2141224543 @default.
- W2793556201 cites W2142909665 @default.
- W2793556201 cites W2144568788 @default.
- W2793556201 cites W2149176609 @default.
- W2793556201 cites W2151672477 @default.
- W2793556201 cites W2158894504 @default.
- W2793556201 cites W2159395295 @default.
- W2793556201 cites W2164175281 @default.
- W2793556201 cites W2164936738 @default.
- W2793556201 cites W2165056748 @default.