FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793585132> ?p ?o ?g. }

• W2793585132 abstract "The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and adaptive immunity. The secret of this functional diversity, in turn, resides in the elegant but complex structure of the C1q molecule, which is assembled from three distinct gene products: A, B, and C, each of which has evolved from a separate and unique ancestral gene template. The C1q molecule is made up of 6A, 6B, and 6C polypeptide chains, which are held together through strong covalent and non-covalent bonds to form the 18-chain, bouquet-of-flower-like protein that we know today. The assembled C1q protein displays at least two distinct structural and functional regions: the collagen-like region (cC1q) and the globular head region (gC1q), each being capable of driving a diverse range of ligand- or receptor-mediated biological functions. What is most intriguing, however, is the observation that most of the functions appear to be predominantly driven by the A-chain of the molecule, which begs the question: what are the evolutionary modifications or rearrangements that singularly shaped the primordial A-chain gene to become a pluripotent and versatile component of the intact C1q molecule? Here, we revisit and discuss some of the known unique structural and functional features of the A-chain, which may have contributed to its versatility." @default.
• W2793585132 created "2018-03-29" @default.
• W2793585132 creator A5012990589 @default.
• W2793585132 creator A5023783979 @default.
• W2793585132 creator A5045255121 @default.
• W2793585132 creator A5062104862 @default.
• W2793585132 date "2018-02-05" @default.
• W2793585132 modified "2023-10-06" @default.
• W2793585132 title "Is the A-Chain the Engine That Drives the Diversity of C1q Functions? Revisiting Its Unique Structure" @default.
• W2793585132 cites W1480792445 @default.
• W2793585132 cites W1521036527 @default.
• W2793585132 cites W1528839689 @default.
• W2793585132 cites W1537575434 @default.
• W2793585132 cites W1547308644 @default.
• W2793585132 cites W1549175877 @default.
• W2793585132 cites W1549447146 @default.
• W2793585132 cites W1559449746 @default.
• W2793585132 cites W1562354149 @default.
• W2793585132 cites W1574593386 @default.
• W2793585132 cites W1601001024 @default.
• W2793585132 cites W1608014870 @default.
• W2793585132 cites W1806019846 @default.
• W2793585132 cites W1820570900 @default.
• W2793585132 cites W1906912370 @default.
• W2793585132 cites W1965327468 @default.
• W2793585132 cites W1976691812 @default.
• W2793585132 cites W1988481978 @default.
• W2793585132 cites W2020388650 @default.
• W2793585132 cites W2023593986 @default.
• W2793585132 cites W2024823875 @default.
• W2793585132 cites W2024886564 @default.
• W2793585132 cites W2036765075 @default.
• W2793585132 cites W2037994603 @default.
• W2793585132 cites W2044305866 @default.
• W2793585132 cites W2045283400 @default.
• W2793585132 cites W2045661424 @default.
• W2793585132 cites W2045972201 @default.
• W2793585132 cites W2047513823 @default.
• W2793585132 cites W2054484507 @default.
• W2793585132 cites W2056059436 @default.
• W2793585132 cites W2061272125 @default.
• W2793585132 cites W2061379582 @default.
• W2793585132 cites W2062162775 @default.
• W2793585132 cites W2063513932 @default.
• W2793585132 cites W2079702499 @default.
• W2793585132 cites W2094661843 @default.
• W2793585132 cites W2101099185 @default.
• W2793585132 cites W2101905781 @default.
• W2793585132 cites W2106728114 @default.
• W2793585132 cites W2107873069 @default.
• W2793585132 cites W2117129725 @default.
• W2793585132 cites W2148024610 @default.
• W2793585132 cites W2228319314 @default.
• W2793585132 cites W2267678719 @default.
• W2793585132 cites W2322147870 @default.
• W2793585132 cites W2336801646 @default.
• W2793585132 cites W2337132279 @default.
• W2793585132 cites W2529440042 @default.
• W2793585132 cites W2573038530 @default.
• W2793585132 cites W2767693897 @default.
• W2793585132 cites W4232045253 @default.
• W2793585132 cites W4290353266 @default.
• W2793585132 doi "https://doi.org/10.3389/fimmu.2018.00162" @default.
• W2793585132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5807628" @default.
• W2793585132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29459870" @default.
• W2793585132 hasPublicationYear "2018" @default.
• W2793585132 type Work @default.
• W2793585132 sameAs 2793585132 @default.
• W2793585132 citedByCount "10" @default.
• W2793585132 countsByYear W27935851322018 @default.
• W2793585132 countsByYear W27935851322019 @default.
• W2793585132 countsByYear W27935851322020 @default.
• W2793585132 countsByYear W27935851322021 @default.
• W2793585132 countsByYear W27935851322022 @default.
• W2793585132 countsByYear W27935851322023 @default.
• W2793585132 crossrefType "journal-article" @default.
• W2793585132 hasAuthorship W2793585132A5012990589 @default.
• W2793585132 hasAuthorship W2793585132A5023783979 @default.
• W2793585132 hasAuthorship W2793585132A5045255121 @default.
• W2793585132 hasAuthorship W2793585132A5062104862 @default.
• W2793585132 hasBestOaLocation W27935851321 @default.
• W2793585132 hasConcept C104317684 @default.
• W2793585132 hasConcept C107110972 @default.
• W2793585132 hasConcept C141231307 @default.
• W2793585132 hasConcept C18903297 @default.
• W2793585132 hasConcept C193419808 @default.
• W2793585132 hasConcept C2988890453 @default.
• W2793585132 hasConcept C54355233 @default.
• W2793585132 hasConcept C70721500 @default.
• W2793585132 hasConcept C78458016 @default.
• W2793585132 hasConcept C86803240 @default.
• W2793585132 hasConcept C8891405 @default.
• W2793585132 hasConceptScore W2793585132C104317684 @default.
• W2793585132 hasConceptScore W2793585132C107110972 @default.
• W2793585132 hasConceptScore W2793585132C141231307 @default.
• W2793585132 hasConceptScore W2793585132C18903297 @default.
• W2793585132 hasConceptScore W2793585132C193419808 @default.
• W2793585132 hasConceptScore W2793585132C2988890453 @default.
• W2793585132 hasConceptScore W2793585132C54355233 @default.
• W2793585132 hasConceptScore W2793585132C70721500 @default.

• next