Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793590421> ?p ?o ?g. }
- W2793590421 endingPage "1179" @default.
- W2793590421 startingPage "1165" @default.
- W2793590421 abstract "Mitochondrial Ca2+ is involved in heterogeneous functions, ranging from the control of metabolism and ATP production to the regulation of cell death. In addition, mitochondrial Ca2+ uptake contributes to cytosolic [Ca2+] shaping thus impinging on specific Ca2+-dependent events. Mitochondrial Ca2+ concentration is controlled by influx and efflux pathways: the former controlled by the activity of the mitochondrial Ca2+ uniporter (MCU), the latter by the Na+/Ca2+ exchanger (NCLX) and the H+/Ca2+ (mHCX) exchanger. The molecular identities of MCU and of NCLX have been recently unraveled, thus allowing genetic studies on their physiopathological relevance. After a general framework on the significance of mitochondrial Ca2+ uptake, this review discusses the structure of the MCU complex and the regulation of its activity, the importance of mitochondrial Ca2+ signaling in different physiological settings, and the consequences of MCU modulation on organ physiology." @default.
- W2793590421 created "2018-03-29" @default.
- W2793590421 creator A5021079841 @default.
- W2793590421 creator A5027748782 @default.
- W2793590421 creator A5052676817 @default.
- W2793590421 creator A5058521509 @default.
- W2793590421 creator A5068450352 @default.
- W2793590421 creator A5073596294 @default.
- W2793590421 date "2018-03-15" @default.
- W2793590421 modified "2023-10-16" @default.
- W2793590421 title "Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models" @default.
- W2793590421 cites W115465126 @default.
- W2793590421 cites W1489283017 @default.
- W2793590421 cites W1496281435 @default.
- W2793590421 cites W1523821352 @default.
- W2793590421 cites W1547216871 @default.
- W2793590421 cites W1555531912 @default.
- W2793590421 cites W1590022473 @default.
- W2793590421 cites W1616183675 @default.
- W2793590421 cites W1622243645 @default.
- W2793590421 cites W1800295875 @default.
- W2793590421 cites W1823461212 @default.
- W2793590421 cites W1963791094 @default.
- W2793590421 cites W1964126982 @default.
- W2793590421 cites W1965893090 @default.
- W2793590421 cites W1967646152 @default.
- W2793590421 cites W1969195108 @default.
- W2793590421 cites W1969709153 @default.
- W2793590421 cites W1981748166 @default.
- W2793590421 cites W1983324471 @default.
- W2793590421 cites W1983408914 @default.
- W2793590421 cites W1986213783 @default.
- W2793590421 cites W1991055482 @default.
- W2793590421 cites W1991216672 @default.
- W2793590421 cites W1995237666 @default.
- W2793590421 cites W1998577671 @default.
- W2793590421 cites W2002475003 @default.
- W2793590421 cites W2005641666 @default.
- W2793590421 cites W2005844165 @default.
- W2793590421 cites W2007636933 @default.
- W2793590421 cites W2008925266 @default.
- W2793590421 cites W2010083809 @default.
- W2793590421 cites W2010986301 @default.
- W2793590421 cites W2015798899 @default.
- W2793590421 cites W2016024763 @default.
- W2793590421 cites W2022324453 @default.
- W2793590421 cites W2025877424 @default.
- W2793590421 cites W2030713769 @default.
- W2793590421 cites W2030845275 @default.
- W2793590421 cites W2031313830 @default.
- W2793590421 cites W2032781637 @default.
- W2793590421 cites W2035213438 @default.
- W2793590421 cites W2035968737 @default.
- W2793590421 cites W2037266625 @default.
- W2793590421 cites W2041874682 @default.
- W2793590421 cites W2043135080 @default.
- W2793590421 cites W2047460306 @default.
- W2793590421 cites W2050824263 @default.
- W2793590421 cites W2052471341 @default.
- W2793590421 cites W2053625924 @default.
- W2793590421 cites W2055857902 @default.
- W2793590421 cites W2059784324 @default.
- W2793590421 cites W2061994372 @default.
- W2793590421 cites W2063107511 @default.
- W2793590421 cites W2063557532 @default.
- W2793590421 cites W2067338987 @default.
- W2793590421 cites W2067477337 @default.
- W2793590421 cites W2067841051 @default.
- W2793590421 cites W2070805734 @default.
- W2793590421 cites W2070869619 @default.
- W2793590421 cites W2072240385 @default.
- W2793590421 cites W2074058787 @default.
- W2793590421 cites W2077996001 @default.
- W2793590421 cites W2078179312 @default.
- W2793590421 cites W2078684933 @default.
- W2793590421 cites W2079388247 @default.
- W2793590421 cites W2080875760 @default.
- W2793590421 cites W2082588556 @default.
- W2793590421 cites W2085111073 @default.
- W2793590421 cites W2088093088 @default.
- W2793590421 cites W2097167248 @default.
- W2793590421 cites W2099869024 @default.
- W2793590421 cites W2101117598 @default.
- W2793590421 cites W2101840868 @default.
- W2793590421 cites W2112384117 @default.
- W2793590421 cites W2114041992 @default.
- W2793590421 cites W2116444561 @default.
- W2793590421 cites W2117660299 @default.
- W2793590421 cites W2117977069 @default.
- W2793590421 cites W2127775546 @default.
- W2793590421 cites W2129483239 @default.
- W2793590421 cites W2130025116 @default.
- W2793590421 cites W2139625864 @default.
- W2793590421 cites W2142294730 @default.
- W2793590421 cites W2142903428 @default.
- W2793590421 cites W2144171388 @default.
- W2793590421 cites W2148332345 @default.
- W2793590421 cites W2151059887 @default.