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- W2793619072 abstract "Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although triggered by a pathogen, pneumonia often results from dysregulations of host defense that likely precede infection. The coordinated activities of immune resistance and tissue resilience then dictate whether and how pneumonia progresses or resolves. Inadequate or inappropriate host responses lead to more severe outcomes such as acute respiratory distress syndrome and to organ dysfunction beyond the lungs and over extended time frames after pathogen clearance, some of which increase the risk for subsequent pneumonia. Improved understanding of such host responses will guide the development of novel approaches for preventing and curing pneumonia and for mitigating the subsequent pulmonary and extrapulmonary complications of pneumonia. The NHLBI assembled a working group of extramural investigators to prioritize avenues of host-directed pneumonia research that should yield novel approaches for interrupting the cycle of unhealthy decline caused by pneumonia. This report summarizes the working group's specific recommendations in the areas of pneumonia susceptibility, host response, and consequences. Overarching goals include the development of more host-focused clinical approaches for preventing and treating pneumonia, the generation of predictive tools (for pneumonia occurrence, severity, and outcome), and the elucidation of mechanisms mediating immune resistance and tissue resilience in the lung. Specific areas of research are highlighted as especially promising for making advances against pneumonia." @default.
- W2793619072 created "2018-03-29" @default.
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- W2793619072 date "2018-07-15" @default.
- W2793619072 modified "2023-10-16" @default.
- W2793619072 title "Future Research Directions in Pneumonia. NHLBI Working Group Report" @default.
- W2793619072 cites W1536524592 @default.
- W2793619072 cites W1967367648 @default.
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- W2793619072 cites W2001153857 @default.
- W2793619072 cites W2012030177 @default.
- W2793619072 cites W2013604456 @default.
- W2793619072 cites W2034443456 @default.
- W2793619072 cites W2038131149 @default.
- W2793619072 cites W2040579661 @default.
- W2793619072 cites W2048351247 @default.
- W2793619072 cites W2053207109 @default.
- W2793619072 cites W2056814521 @default.
- W2793619072 cites W2070197274 @default.
- W2793619072 cites W2083439621 @default.
- W2793619072 cites W2083850524 @default.
- W2793619072 cites W2087337981 @default.
- W2793619072 cites W2105981152 @default.
- W2793619072 cites W2106460540 @default.
- W2793619072 cites W2108337616 @default.
- W2793619072 cites W2114698211 @default.
- W2793619072 cites W2116581803 @default.
- W2793619072 cites W2128190958 @default.
- W2793619072 cites W2129045572 @default.
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- W2793619072 cites W2131964383 @default.
- W2793619072 cites W2142413409 @default.
- W2793619072 cites W2155051381 @default.
- W2793619072 cites W2156749754 @default.
- W2793619072 cites W2158860487 @default.
- W2793619072 cites W2160739269 @default.
- W2793619072 cites W2167320417 @default.
- W2793619072 cites W2168953810 @default.
- W2793619072 cites W2170374271 @default.
- W2793619072 cites W2180849422 @default.
- W2793619072 cites W2192331777 @default.
- W2793619072 cites W2198808464 @default.
- W2793619072 cites W2272836689 @default.
- W2793619072 cites W2273717373 @default.
- W2793619072 cites W2301131921 @default.
- W2793619072 cites W2325719910 @default.
- W2793619072 cites W2332152786 @default.
- W2793619072 cites W2336656712 @default.
- W2793619072 cites W2337334490 @default.
- W2793619072 cites W2359840338 @default.
- W2793619072 cites W2405019496 @default.
- W2793619072 cites W2411583672 @default.
- W2793619072 cites W2415335372 @default.
- W2793619072 cites W2474277182 @default.
- W2793619072 cites W2502481781 @default.
- W2793619072 cites W2535312870 @default.
- W2793619072 cites W2561758149 @default.
- W2793619072 cites W2582807481 @default.
- W2793619072 cites W2588237306 @default.
- W2793619072 cites W2594920743 @default.
- W2793619072 cites W2604938386 @default.
- W2793619072 cites W2607350314 @default.
- W2793619072 cites W2612986562 @default.
- W2793619072 cites W2614796552 @default.
- W2793619072 cites W2616766770 @default.
- W2793619072 cites W2619163335 @default.
- W2793619072 cites W2623550656 @default.
- W2793619072 cites W2689866037 @default.
- W2793619072 cites W2728411043 @default.