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• W2793644332 abstract "Chronic skin diseases with itch and dry skin show increased peripheral nerve fiber elongation into the epidermis. However, the characteristics of the elongated nerve fibers remain unclear. Therefore, we investigated the characteristics of the elongated nerve fibers using a dry skin mouse model with itch. In this mouse model, prepared via repetitive treatments with an acetone/ether mixture and water, the stratum corneum water content was decreased, whereas spontaneous scratching and epidermal hyperplasia were increased. In addition, the number of substance P (SP)- and calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers (C-fibers) was increased in the epidermis of treated mice compared to that in non-treated control mice. However, neurofilament 200-immunoreactive nerve fibers (A-fibers) were not detected in the epidermis of treated mice. These results suggest that the elongated epidermal peripheral nerve fibers comprise SP/CGRP-containing C-fibers but not A-fibers. Thus, these fibers may be involved in the induction of dry skin pruritus." @default.
• W2793644332 created "2018-03-29" @default.
• W2793644332 creator A5015224921 @default.
• W2793644332 creator A5054175171 @default.
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• W2793644332 date "2018-04-01" @default.
• W2793644332 modified "2023-10-11" @default.
• W2793644332 title "Non-myelinated C-fibers, but not myelinated A-fibers, elongate into the epidermis in dry skin with itch" @default.
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• W2793644332 doi "https://doi.org/10.1016/j.neulet.2018.02.034" @default.
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