Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793670085> ?p ?o ?g. }
- W2793670085 endingPage "555.e6" @default.
- W2793670085 startingPage "542" @default.
- W2793670085 abstract "Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 (mTORC2) led to inhibition of glycogen synthase kinase 3β (GSK3β) at mitochondria-endoplasmic reticulum (ER) junctions. This enabled recruitment of hexokinase I (HK-I) to the voltage-dependent anion channel (VDAC) on mitochondria. Binding of HK-I to VDAC promoted respiration by facilitating metabolite flux into mitochondria. Glucose tracing pinpointed pyruvate oxidation in mitochondria, which was the metabolic requirement for rapid generation of interferon-γ (IFN-γ) in memory T cells. Subcellular organization of mTORC2-AKT-GSK3β at mitochondria-ER contact sites, promoting HK-I recruitment to VDAC, thus underpins the metabolic reprogramming needed for memory CD8+ T cells to rapidly acquire effector function." @default.
- W2793670085 created "2018-03-29" @default.
- W2793670085 creator A5003476561 @default.
- W2793670085 creator A5004102058 @default.
- W2793670085 creator A5012990096 @default.
- W2793670085 creator A5013025718 @default.
- W2793670085 creator A5013887971 @default.
- W2793670085 creator A5016111454 @default.
- W2793670085 creator A5019302340 @default.
- W2793670085 creator A5029269481 @default.
- W2793670085 creator A5033546291 @default.
- W2793670085 creator A5033957720 @default.
- W2793670085 creator A5039593933 @default.
- W2793670085 creator A5040731842 @default.
- W2793670085 creator A5047090078 @default.
- W2793670085 creator A5056293614 @default.
- W2793670085 creator A5059363941 @default.
- W2793670085 creator A5061708060 @default.
- W2793670085 creator A5066512472 @default.
- W2793670085 creator A5071971878 @default.
- W2793670085 creator A5080001856 @default.
- W2793670085 creator A5082048176 @default.
- W2793670085 creator A5084648395 @default.
- W2793670085 creator A5087077382 @default.
- W2793670085 creator A5087857002 @default.
- W2793670085 date "2018-03-01" @default.
- W2793670085 modified "2023-10-17" @default.
- W2793670085 title "Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells" @default.
- W2793670085 cites W1974117358 @default.
- W2793670085 cites W1976714959 @default.
- W2793670085 cites W1981480494 @default.
- W2793670085 cites W1985538633 @default.
- W2793670085 cites W1990423632 @default.
- W2793670085 cites W1994186363 @default.
- W2793670085 cites W2006192795 @default.
- W2793670085 cites W2029801534 @default.
- W2793670085 cites W2052408923 @default.
- W2793670085 cites W2052622892 @default.
- W2793670085 cites W2058138221 @default.
- W2793670085 cites W2061318708 @default.
- W2793670085 cites W2069749184 @default.
- W2793670085 cites W2084317828 @default.
- W2793670085 cites W2094999489 @default.
- W2793670085 cites W2096579721 @default.
- W2793670085 cites W2101840868 @default.
- W2793670085 cites W2105697998 @default.
- W2793670085 cites W2113847305 @default.
- W2793670085 cites W2131199230 @default.
- W2793670085 cites W2131952786 @default.
- W2793670085 cites W2142583550 @default.
- W2793670085 cites W2143505819 @default.
- W2793670085 cites W2144575277 @default.
- W2793670085 cites W2146947580 @default.
- W2793670085 cites W2148749720 @default.
- W2793670085 cites W2169060223 @default.
- W2793670085 cites W2170638980 @default.
- W2793670085 cites W2252585899 @default.
- W2793670085 cites W2288568691 @default.
- W2793670085 cites W2401038200 @default.
- W2793670085 cites W2408556053 @default.
- W2793670085 cites W2415427537 @default.
- W2793670085 cites W2420118023 @default.
- W2793670085 cites W2460289322 @default.
- W2793670085 cites W2522590448 @default.
- W2793670085 cites W2523989131 @default.
- W2793670085 cites W2529623160 @default.
- W2793670085 cites W2760375764 @default.
- W2793670085 doi "https://doi.org/10.1016/j.immuni.2018.02.012" @default.
- W2793670085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6049611" @default.
- W2793670085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29523440" @default.
- W2793670085 hasPublicationYear "2018" @default.
- W2793670085 type Work @default.
- W2793670085 sameAs 2793670085 @default.
- W2793670085 citedByCount "116" @default.
- W2793670085 countsByYear W27936700852018 @default.
- W2793670085 countsByYear W27936700852019 @default.
- W2793670085 countsByYear W27936700852020 @default.
- W2793670085 countsByYear W27936700852021 @default.
- W2793670085 countsByYear W27936700852022 @default.
- W2793670085 countsByYear W27936700852023 @default.
- W2793670085 crossrefType "journal-article" @default.
- W2793670085 hasAuthorship W2793670085A5003476561 @default.
- W2793670085 hasAuthorship W2793670085A5004102058 @default.
- W2793670085 hasAuthorship W2793670085A5012990096 @default.
- W2793670085 hasAuthorship W2793670085A5013025718 @default.
- W2793670085 hasAuthorship W2793670085A5013887971 @default.
- W2793670085 hasAuthorship W2793670085A5016111454 @default.
- W2793670085 hasAuthorship W2793670085A5019302340 @default.
- W2793670085 hasAuthorship W2793670085A5029269481 @default.
- W2793670085 hasAuthorship W2793670085A5033546291 @default.
- W2793670085 hasAuthorship W2793670085A5033957720 @default.
- W2793670085 hasAuthorship W2793670085A5039593933 @default.
- W2793670085 hasAuthorship W2793670085A5040731842 @default.
- W2793670085 hasAuthorship W2793670085A5047090078 @default.
- W2793670085 hasAuthorship W2793670085A5056293614 @default.
- W2793670085 hasAuthorship W2793670085A5059363941 @default.
- W2793670085 hasAuthorship W2793670085A5061708060 @default.
- W2793670085 hasAuthorship W2793670085A5066512472 @default.