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- W2793721007 startingPage "095010" @default.
- W2793721007 abstract "Histotripsy is a form of therapeutic ultrasound that liquefies tissue mechanically via acoustic cavitation. Bubble expansion is paramount in the efficacy of histotripsy therapy, and the cavitation dynamics are strongly influenced by the medium elasticity. In this study, an analytic model to predict histotripsy-induced bubble expansion in a fluid was extended to include the effects of medium elasticity. Good agreement was observed between the predictions of the analytic model and numerical computations utilizing highly nonlinear excitations (shock-scattering histotripsy) and purely tensile pulses (microtripsy). No bubble expansion was computed for either form of histotripsy when the elastic modulus was greater than 20 MPa and the peak negative pressure was less than 50 MPa. Strain in the medium due to the expansion of a single bubble was also tabulated. The viability of red blood cells was calculated as a function of distance from the bubble wall based on empirical data of impulsive stretching of erythrocytes. Red blood cells remained viable at distances further than 44 µm from the bubble wall. As the medium elasticity increased, the distance over which bubble expansion-induced strain influenced red blood cells was found to decrease sigmoidally. These results highlight the relationship between tissue elasticity and the efficacy of histotripsy. In addition, an upper medium elasticity limit was identified, above which histotripsy may not be effective for tissue liquefaction." @default.
- W2793721007 created "2018-03-29" @default.
- W2793721007 creator A5082743141 @default.
- W2793721007 date "2018-05-02" @default.
- W2793721007 modified "2023-09-27" @default.
- W2793721007 title "The influence of medium elasticity on the prediction of histotripsy-induced bubble expansion and erythrocyte viability" @default.
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- W2793721007 doi "https://doi.org/10.1088/1361-6560/aab79b" @default.
- W2793721007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5959013" @default.
- W2793721007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29553049" @default.
- W2793721007 hasPublicationYear "2018" @default.
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