Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793730002> ?p ?o ?g. }
- W2793730002 endingPage "75" @default.
- W2793730002 startingPage "63" @default.
- W2793730002 abstract "The present study describes the fabrication of Tripolyphosphate (TPP)-crosslinked nanofibrous mats based on chitosan for use as a floating gastro-retentive delivery system. TPP-crosslinked chitosan (CH)/poly (ethylene oxide) (PEO)- ranitidine hydrochloride (RH) electrospun nanofibers (75.27 ± 2.10 nm) were prepared by electrospinning 70% v/v acetic acid solutions, and followed by crosslinking by TPP anions. The mechanical, structural and morphological properties of the prepared nanofibers were evaluated via tensile testing, XRD, FT-IR, TGA, NMR, AFM and SEM experimental techniques. The prepared nanofibrous mats showed a pH sensitive swelling profile with maximum water absorbing at pH 1.2. Results obtained from above experimental techniques indicated that crosslinking process did not significantly altered morphological property of nanofibers but rather decreased their diameter and swelling degree, and increased their mechanical properties, thermal stability and bioadhesive strength. Viscosity measurements showed that the addition of PEO and RH to the chitosan solution, depending to its concentration lead to decrease in the viscosity of its solution. Also, floating test showed that the prepared nanofibrous mats remain floated onto surface of the dissolution medium for more than 48 h. Based on in- vitro drug release data analysis, TPP-crosslinked CH/PEO nanofibrous mats decreased initial burst release and it was exhibited a sustained release profile for the RH from the TPP-crosslinked CH/PEO-RH electrospun nanofibrous mats." @default.
- W2793730002 created "2018-03-29" @default.
- W2793730002 creator A5020785344 @default.
- W2793730002 creator A5031541057 @default.
- W2793730002 creator A5063656691 @default.
- W2793730002 creator A5083563836 @default.
- W2793730002 date "2018-05-01" @default.
- W2793730002 modified "2023-10-02" @default.
- W2793730002 title "Tripolyphosphate-crosslinked chitosan/poly (ethylene oxide) electrospun nanofibrous mats as a floating gastro-retentive delivery system for ranitidine hydrochloride" @default.
- W2793730002 cites W1923009415 @default.
- W2793730002 cites W1967708372 @default.
- W2793730002 cites W1968810582 @default.
- W2793730002 cites W1975685052 @default.
- W2793730002 cites W1976467447 @default.
- W2793730002 cites W1983733862 @default.
- W2793730002 cites W1992287346 @default.
- W2793730002 cites W1996823723 @default.
- W2793730002 cites W2000864034 @default.
- W2793730002 cites W2008188609 @default.
- W2793730002 cites W2010144404 @default.
- W2793730002 cites W2011984934 @default.
- W2793730002 cites W2012836594 @default.
- W2793730002 cites W2014381718 @default.
- W2793730002 cites W2019402521 @default.
- W2793730002 cites W2021250214 @default.
- W2793730002 cites W2021433090 @default.
- W2793730002 cites W2026959857 @default.
- W2793730002 cites W2027509252 @default.
- W2793730002 cites W2031168361 @default.
- W2793730002 cites W2036332668 @default.
- W2793730002 cites W2046708661 @default.
- W2793730002 cites W2061742628 @default.
- W2793730002 cites W2069885449 @default.
- W2793730002 cites W2074681129 @default.
- W2793730002 cites W2083122663 @default.
- W2793730002 cites W2083567748 @default.
- W2793730002 cites W2086853130 @default.
- W2793730002 cites W2087966138 @default.
- W2793730002 cites W2088592669 @default.
- W2793730002 cites W2119997814 @default.
- W2793730002 cites W2120890333 @default.
- W2793730002 cites W2122993427 @default.
- W2793730002 cites W2136034033 @default.
- W2793730002 cites W2141740137 @default.
- W2793730002 cites W2151868155 @default.
- W2793730002 cites W2152037155 @default.
- W2793730002 cites W2156026112 @default.
- W2793730002 cites W2164547260 @default.
- W2793730002 cites W2185180747 @default.
- W2793730002 cites W2222524673 @default.
- W2793730002 cites W2273413083 @default.
- W2793730002 cites W2301563261 @default.
- W2793730002 cites W2314696823 @default.
- W2793730002 cites W2345335071 @default.
- W2793730002 cites W2345481275 @default.
- W2793730002 cites W2466622700 @default.
- W2793730002 cites W2473031073 @default.
- W2793730002 cites W2477731609 @default.
- W2793730002 cites W2491242632 @default.
- W2793730002 cites W2517133976 @default.
- W2793730002 cites W2520020402 @default.
- W2793730002 cites W2527703094 @default.
- W2793730002 cites W2534166556 @default.
- W2793730002 cites W2542021857 @default.
- W2793730002 cites W2547882780 @default.
- W2793730002 cites W2591309114 @default.
- W2793730002 cites W2595131944 @default.
- W2793730002 cites W2610683705 @default.
- W2793730002 cites W2611787241 @default.
- W2793730002 cites W2611894617 @default.
- W2793730002 cites W2617037037 @default.
- W2793730002 cites W2617460031 @default.
- W2793730002 cites W2742343416 @default.
- W2793730002 cites W2743686038 @default.
- W2793730002 cites W2765545197 @default.
- W2793730002 cites W2777808328 @default.
- W2793730002 cites W2783241014 @default.
- W2793730002 cites W2784030914 @default.
- W2793730002 doi "https://doi.org/10.1016/j.jpba.2018.02.023" @default.
- W2793730002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29462781" @default.
- W2793730002 hasPublicationYear "2018" @default.
- W2793730002 type Work @default.
- W2793730002 sameAs 2793730002 @default.
- W2793730002 citedByCount "38" @default.
- W2793730002 countsByYear W27937300022018 @default.
- W2793730002 countsByYear W27937300022019 @default.
- W2793730002 countsByYear W27937300022020 @default.
- W2793730002 countsByYear W27937300022021 @default.
- W2793730002 countsByYear W27937300022022 @default.
- W2793730002 countsByYear W27937300022023 @default.
- W2793730002 crossrefType "journal-article" @default.
- W2793730002 hasAuthorship W2793730002A5020785344 @default.
- W2793730002 hasAuthorship W2793730002A5031541057 @default.
- W2793730002 hasAuthorship W2793730002A5063656691 @default.
- W2793730002 hasAuthorship W2793730002A5083563836 @default.
- W2793730002 hasConcept C112950240 @default.
- W2793730002 hasConcept C127413603 @default.
- W2793730002 hasConcept C13965031 @default.